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1468 
Technical Report 
Guidelines for the health risk assessment of chemical mixtures 
U.S. Environmental Protection Agency :: U.S. EPA 
1986 
U.S. Environmental Protection Agency, Risk Assessment Forum 
Washington, DC 
EPA/630/R-98/002 
1-38 
38 
English 
has other version or edition 1157975 Guidelines for the health risk assessment of chemical mixtures
The 1986 Guidelines for the Health Risk Assessment of Chemical Mixtures represent the Agency's science policy and are a procedural guide for evaluating data on the health risks from exposures to chemical mixtures. The emphasis is on dose response and risk characterization. 
• Ammonia
     Literature Search – March 2012 (private)
     Literature Search Results
     Not Chemical Specific
          Guidance, notices
• Asbestos
• Benzo(a)pyrene (BaP)
     Considered
     Cited
          Guidance
• Biphenyl
     Considered
     Cited References
          Guidance
• tert-Butanol
     Cited in Document
• n-Butanol
     • Cited 2016 Public Comment Draft
          Tox Review
• tert-Butanol
     Cited in Public Comment Draft – May 2016
          Toxicological Review
• Chloroform Combined (current)
     Chloroform (original)
• Chloroprene
     Cited 2009 Draft
     Cited 2010 Final
• DCM (Dichloromethane) (Final, 2011)
• Diisobutyl Phthalate (DIBP) Final
     Additional Search Strategies
          References obtained during assessment process
     No Primary Data on Toxic Effects
          Not chemical specific
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• Dioxin (2012 Project Page for Final Report)
• Formaldehyde
     Cited in text
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Cited in External Review Draft (2011)
• PCBs
     Cited (Nov 2012)
• RDX (121-82-4)
     Cited 2015 (private)
• Tetrachloroethylene (Perc) (Final, 2012)
     All References
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
• Trimethylbenzenes (Interagency Science Discussion Draft)
     Primary Literature Search
     Primary Literature Search- Considered
• Trimethylbenzenes (TMB)
     Considered Studies
          Other
     Cited Studies
          Guidance
          EPA
     Cited in Tox Review – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Vanadium Compounds - Problem Formulation
     Manual review of existing IRIS and PPRTV assessments
          IRIS 2011/2014
     Combined data set
          Dataset for title/abstract screening
               Excluded- PECO criteria not met (TIAB)
• Vanadium Pentoxide (Draft, 2011)
OPPT REs
• OPPT_1,4-Dioxane_C. Engineering
     Data screening total
          Screening: Excluded
• OPPT_1,4-Dioxane_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_C. Engineering
• OPPT_Carbon Tetrachloride_D. Exposure
• OPPT_Carbon Tetrachloride_E. Fate
• OPPT_Carbon Tetrachloride_F. Human Health
• OPPT_Methylene Chloride_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Secondary source/ Review
               Cited in IRIS document or IRIS HERO page
• OPPT_Trichloroethylene (TCE)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_F. Human Health
     Total – title/abstract screening
          Off topic
Other
• Exposure Factors Handbook (Post 2011)
     Chapter 1