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10680 
Journal Article 
Mutagenicity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells 
Drevon, C; Kuroki, T 
1979 
1 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
ELSEVIER SCIENCE BV 
AMSTERDAM 
HEEP/80/02308 
Mutat Res. 
67 
2 
173-182 
English 
470972 
WOS:A1979HA86700009 
The mutagenicity of vinyl chloride, vinylidene chloride (1,1-dichloroethylene) and chloroprene (2-chloro-1,3-butadiene) was tested in V79 Chinese hamster cells in the presence of a 15 000 x g liver supernatant from phenobarbitone-pre-treated rats and mice. Mutations in terms of 8-azaguanine and ouabain resistance were induced in a dose-related fasion by exposure to vapour of vinyl chloride in the presence of liver supernatant from phenobarbitone-pretreated rats. Vapours of vinylidene chloride and chloroprene induced a dose-related toxicity in the presence of liver supernatant from phenobarbitone-retreated rats, but these two compounds were not mutagenic in V79 Chinese hamster cells under the present assay conditions. The results are discussed with regard to the metabolic activation of the compounds and to the correlation with their carcinogenicity in man and experimental animals. 
Butadienes; Dichloroethylenes; Hydrocarbons, Chlorinated; Mutagens; Vinyl Compounds; Chloroprene; 126-99-8; Ouabain; 5ACL011P69; Azaguanine; Q150359I72; Vinyl Chloride; WD06X94M2D; Index Medicus; Dose-Response Relationship, Drug; Cell Line; Ouabain -- pharmacology; Cricetinae; Phenotype; Animals; Cricetulus; Drug Evaluation, Preclinical; Azaguanine -- pharmacology; Drug Resistance; Dichloroethylenes -- pharmacology; Vinyl Chloride -- pharmacology; Vinyl Compounds -- pharmacology; Chloroprene -- pharmacology; Butadienes -- pharmacology; Hydrocarbons, Chlorinated -- pharmacology 
IRIS
• Chloroprene
     Cited 2009 Draft
     Cited 2010 Final