Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
100147
Reference Type
Journal Article
Title
Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his
Author(s)
Hoflack, JC; Lambolez, L; Elias, Z; Vasseur, P
Year
1995
Is Peer Reviewed?
1
Journal
Mutation Research
ISSN:
0027-5107
EISSN:
1873-135X
Report Number
EMIC/96085
Volume
341
Issue
4
Page Numbers
281-287
Language
English
PMID
7531287
DOI
10.1016/0165-1218(95)90099-3
Web of Science Id
WOS:A1995QF13700005
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7531287
Exit
Abstract
Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenicity with the Ames test. The Salmonella typhimurium his- tester strains TA 97a, TA 98, TA 100 and TA 102 were used with and without rat S9 mix. Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol n-butyl ether and their corresponding aldehyde and acid derivatives were tested up to 10(-4) mol/plate (around 10 mg/plate) or up to cytotoxic concentrations. All tested substances gave negative results with TA 98, TA 100 and TA 102 either with or without S9 mix. In contrast, ethylene glycol n-butyl ether (EGBE) and the aldehyde metabolite of ethylene glycol monomethyl ether, methoxyacetaldehyde (MALD), displayed mutagenic potency in strain TA 97a with and without S9 mix at high concentrations. A significant number of revertants was obtained from 19 mumol/plate EGBE (2.2 mg/plate) and from 34 mumol/plate MALD (2.5 mg/plate). At these concentrations the level of revertants reached up to 7-fold and 3-fold the control values for EGBE and MALD respectively.
Keywords
Acetaldehyde/analogs & derivatives; Acetic Acid; Acetic Acids/chemistry/toxicity; Biotransformation; Ethers/toxicity; Ethylene Glycols/metabolism/*toxicity; Mutagenicity Tests; Mutagens/metabolism/*toxicity; Salmonella typhimurium
Tags
•
PCBs
2017 Restored References_Dec 2023
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity