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Citation
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HERO ID
625206
Reference Type
Technical Report
Title
Inhalation developmental toxicology studies: Developmental toxicity of chloroprene vapors in New Zealand White rabbits
Author(s)
Mast, TJ; Evanhoff, JJ; Westerberg, RL; Weigel, RJ; Rommereim, RL
Year
1994
Publisher
U.S. Department of Health and Human Services
Location
Research Triangle Park, NC
Report Number
PNL-7458; DE94012384
Abstract
Chloroprene, 2-chloro-1,3-butadiene, is a colorless liquid with a pungent ethereal odor that is primarily used as an intermediate in the manufacture of neoprene rubber, and has been used as such since about 1930. This study addressed the potential for chloroprene to cause developmental toxicity in New Zealand white rabbits following gestational exposure to 0, 10, 40, or 175 ppm chloroprene vapors, 6h/dy, 7dy/wk. Each treatment group consisted of 15 artificially inseminated females exposed on 6 through 28 days of gestation (dg). Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice on 29 dg. Implants were enumerated and their status recorded and live fetuses were examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. There were no overt signs of maternal toxicity and the change in maternal body weight over the course of the study was not affected. Exposure of pregnant rabbits to chloroprene vapors on 6-28 dg had no effect on the number of implantation, the mean percent of live pups per litter, or on the incidence of resorptions per litter. The incidence of fetal malformations was not increased by exposure to chloroprene. Results of this study indicate that gestational exposure of New Zealand white rabbits to 10, 40, or 175 ppm chloroprene did not result in observable toxicity to either the dam or the offspring.
Tags
IRIS
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
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