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Citation
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HERO ID
193493
Reference Type
Journal Article
Title
Human skin penetration of silver nanoparticles through intact and damaged skin
Author(s)
Larese, FF; D'Agostin, F; Crosera, M; Adami, G; Renzi, N; Bovenzi, M; Maina, G
Year
2009
Is Peer Reviewed?
1
Journal
Toxicology
ISSN:
0300-483X
EISSN:
1879-3185
Volume
255
Issue
1-2
Page Numbers
33-37
URL
http://www.ncbi.nlm.nih.gov/pubmed/=18973786
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Abstract
There is a growing interest on nanoparticle safety for topical use. The benefits of nanoparticles have been shown in several scientific fields, but little is known about their potential to penetrate the skin. This study aims at evaluating in vitro skin penetration of silver nanoparticles. Experiments were performed using the Franz diffusion cell method with intact and damaged human skin. Physiological solution was used as receiving phase and 70 microg/cm2 of silver nanoparticles coated with polyvinylpirrolidone dispersed in synthetic sweat were applied as donor phase to the outer surface of the skin for 24h. The receptor fluid measurements were performed by electro thermal atomic absorption spectroscopy (ETAAS). Human skin penetration was also determined by using transmission electron microscope (TEM) to verify the location of silver nanoparticles in exposed membranes. Median silver concentrations of 0.46 ng cm(-2) (range
Tags
•
Nanoscale Silver
External Review Draft
Final Case Study
Exposure, Uptake and Dose
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