Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

157644

Reference Type

Journal Article

Title

Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin

Author(s)

Rouse, JG; Yang, J; Ryman-Rasmussen, JP; Barron, AR; Monteiro-Riviere, NA

Year

2007

Is Peer Reviewed?

Journal

Nano Letters
ISSN: 1530-6984
EISSN: 1530-6992

Volume

Issue

Page Numbers

155-160

DOI

10.1021/nl062464m

Abstract

Dermatomed porcine skin was fixed to a flexing device and topically dosed with 33.5 mg.mL-1 of an aqueous solution of a fullerene-substituted phenylalanine (Baa) derivative of a nuclear localization peptide sequence (Baa-Lys(FITC)-NLS). Skin was flexed for 60 or 90 min or left unflexed (control). Confocal microscopy depicted dermal penetration of the nanoparticles at 8 h in skin flexed for 60 and 90 min, whereas Baa-Lys(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h. TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum.