IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update)
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Abstract
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of naphthalene that when finalized will appear on the Integrated Risk Information System (IRIS) database.
Naphthalene (CAS no. 91-20-3) is a bicyclic aromatic hydrocarbon with the chemical formula C10H8 and a molecular weight of 128.16. Pure naphthalene is a white, water-insoluble solid at room temperature with a vapor pressure of 0.087 mmHg (U.S. EPA, 1987; ATSDR,1993). Naphthalene is produced by distillation and fractionation of either petroleum or coal tar. Naphthalene’s principal use is as an intermediate in the production of phthalic anhydride. Phthalic anhydride is important in the manufacture of phthalate plasticizers, resins, dyes as well as insect and animal repellents. Naphthalene is also used in the manufacture of synthetic leather tanning agents and the insecticide carbaryl. Naphthalene has been used as a moth repellent and as a deodorizer for diaper pails and toilets (ATSDR, 1993; U.S. EPA, 1980, 1987).
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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Naphthalene - Revised June 2004 - (Inhalation cancer assessment and other selected text, as indicated) (PDF) (129 pp, 535 KB, about PDF)
- IRIS SUMMARY OF THE REASSESSMENT OF THE INHALATION CARCINOGENICITY OF NAPHTHALENE (EXTERNAL REVIEW DRAFT) (PDF) (28 pp, 200 KB, about PDF)
- Charge to External Reviewers for the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene June 2004 (PDF) (NA pp, 67 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (30 pp, 221 KB, about PDF)