Toxicological Review of Chloroprene [and IRIS Summary] NCEA-S-0932, October 2000, External Review Draft EPA is providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of chloroprene (CAS No. 126-99-8). These documents are provided for public viewing during an external scientific peer review period.
Benchmark Dose Software The Benchmark Dose Software and pages have been updated. Review the new changes here. Registration is required.
October 26, 2000
Strategy for Research on Environmental Risks to Children EPA/600/R-00/068 October 2000 The EPA's Office of Research and Development has completed the Strategy for Research on Environmental Risks to Children, which provides the strategic direction for ORD's research program in children's health.
October 25, 2000
Reference Dose for Methylmercury NCEA S-0932 October 2000 External Review Draft The draft document is being made available during an external scientific peer-review period. It will be reviewed by a panel of experts at a peer-review workshop on November 15, 2000. The Agency also is accepting comments from the public during a limited public review and comment period.
The QTracer Program for Tracer-Breakthrough Curve Analysis for Karst and Fractured-Rock Aquifers EPA/600/R-98/156a, February 1999 The draft document is being made available during an external scientific peer-review period. It will be reviewed by a panel of experts at a peer-review workshop on November 15, 2000. The Agency also is accepting comments from the public during a limited public review and comment period.
October 3, 2000
Global Change Research Strategy Office of Research and Development's Global Change Research Strategy is publicly available for review and comment.
September 28, 2000
Dioxin Reassessment EPA is releasing three draft chapters of its dioxin reassessment for review by the Agency's Science Advisory Board (SAB) and for public comment. EPA is also making available the current working drafts of the other parts of the dioxin reassessment as well as fact sheets that provide background information on the reassessment and EPA's dioxin risk management efforts.
September 12, 2000
Ecological Risk Assessment Workshop The workshop described in this report was conducted to further develop and document the process for the risk characterization phase of watershed-scale ecological risk assessment. The recommendations reflect the responses of workshop participants to charge questions addressing those aspects of watershed-scale ecological risk characterization deemed most in need of a procedural framework.
August 25, 2000
Toxicological Review of Quinoline [and IRIS Summary] NCEA-S-0883 August 2000 External Review Draft EPA is providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of quinoline (CAS No. 91-22-5). These documents are provided for public infromation during an external scientific peer review period.
August 23, 2000
CatReg Software for Categorical Regression Analysis CatReg is a computer program, written in the S-PLUS. (MathSoft, Inc.) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regression analyses on toxicity data after effects have been assigned to ordinal severity categories (e.g., no effect, adverse effect, severe effect) and associated with up to two independent variables corresponding to the exposure conditions (e.g., concentration and duration) under which the effects occurred.
August 23, 2000
Presidential Commission on Risk Assessment and Risk Management from September 26, 1997. The Presidential/Congressional Commission on Risk Assessment and Risk Management, which was mandated as part of the Clean Air Act Amendments of 1990, was disbanded on August 31, 1997, with some staff work continuing into September. The reports and associated documents of the Commission are being made available on the NCEA web site.
August 21, 2000
Toxicological Review of Acetaldehyde [and IRIS Summary] NCEA-S-0687, July 2000 External Review Draft, PDF Version (170K) EPA is providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of acetaldehyde (CAS No. 75-07-0). These documents are provided for public information during an external scientific peer review period.
August 17, 2000
Toxicological Review of Methyl Chloride [and IRIS Summary] NCEA S-0877, July 2000, External Review Draft EPA is providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of methyl chloride (CAS No. 74-87-3). These documents are provided for public viewing during an external scientific peer review period.
August 17, 2000
Child-Specific Exposure Factors Handbook NCEA-W-0853 June 2000 External Review Draft Although the National Center for Environmental Assessment (NCEA) has published the Exposure Factors Handbook in 1997 (EPA/600/P-95/002Fa-c), which includes exposure factors and related data on both adults and children, the EPA Program Offices identified the need to consolidate all children exposure data into one document. The goal of the Child-Specific Exposure Factors Handbook is to fulfill this need. The document provides a summary of the available and up-to-date statistical data on various factors assessing children exposures.
August 10, 2000
EPA Air Quality Criteria for Carbon Monoxide The U.S. Environmental Protection Agency (EPA) promulgates the National Ambient Air Quality Standards (NAAQS) on the basis of scientific information contained in criteria documents. The last air quality criteria document for carbon monoxide (CO) was completed by EPA in 1991. This revised criteria document consolidates and updates the current scientific basis for another reevaluation of the NAAQS for CO, currently set at 9 ppm (10 mg/m3) for 8 h and 35 ppm (40 mg/m3) for 1 h.
Health Assessment Document for Diesel Exhaust EPA/600/8-90/057E, July 2000, SAB Review Draft EPA is releasing a revised draft Health Assessment Document for Diesel Exhaust. The draft assessment will be peer-reviewed by the Clean Air Scientific Advisory Committee (CASAC) of the EPA's Science Advisory Board in the Fall of 2000 and NCEA will accept public comments. Details of the CASAC meeting and the public comment period will be announced in the Federal Register.
August 3, 2000
Hexachlorocyclopentadiene: External Review Drafts of IRIS Documents EPA is providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of hexachlorocyclopentadiene (CAS No. 77-47-4). These documents are provided for public information during an external scientific peer review period.
June 12, 2000
Draft Dioxin Reassessment EPA is releasing two draft chapters of its dioxin reassessment for peer review and public comment. EPA is also making available the current working drafts of the other parts of the dioxin reassessment as well as fact sheets that provide background information on the reassessment and EPA's dioxin risk management efforts. Note: These documents have been superseded by September 2000 draft documents which will be reviewed by EPA's Science Advisory Board and which are now available on the web.
The Effects of Ammonium Perchlorate on Thyroids Pathology Working Group Report In response to recommendations made at the February 1999 external peer review of the December 1998 document entitled, Perchlorate Environmental Contamination: Toxicology Review and Risk Characterization (http://www.epa.gov/ncea/perch.htm), the National Center for Environmental Assessment (NCEA) arranged for a review of the thyroids from all of the studies by independent pathologists using a consistent lesion grading scheme and to then convene a pathology working group (PWG). The objective of this review was to perform a review by a second pathologist, that had not been performed for any of the individual studies, and which is traditionally accomplished before convening a PWG. Because of the potential for inconsistency across the studies due to the fact that the various studies had been performed by several different laboratories with several different study pathologists using different lesion grading systems, which made use of these data difficult for comparison and development of dose-response analyses, the purpose of the independent peer review and PWG was to decrease variability in response across the studies by providing a common nomenclature for lesions and a consistent pathology review.
April 11, 2000
MTBE and Fuel Oxygenates MTBE and fuel oxygenates have been the subject of health risk assessments and research strategies prepared by the National Center for Environmental Assessment (NCEA).
Toxicology and Risk Assessment Approaches for the 21st Century Conference April 10-13, 2000 Kings Island, OH An interagency conference sponsored by Tri-Service Toxicology; the National Center for Environmental Assessment, United States Environmental Protection Agency; the Division of Toxicology, Agency for Toxic Substances and Disease Registry; the National Institute for Occupational Safety and Health; and with the cooperation of the National Research Council/National Academy of Sciences. NOTE: This web page is no longer available.
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