IRIS Toxicological Review and Summary Documents for N-Hexane (External Review Draft)

Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.

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Notice

Comments on this document may be submitted and viewed using EPA's http://www.epa.gov/edocket Select "search" and key in the Docket Number ORD-2005-0007. As published in the February 11, 2005, Federal Register Notice, all comments must be submitted by Monday, March 11, 2005. The peer-review panel meeting will begin on March 30, 2005, at 9:00 a.m. and end at 3:00 p.m. To attend the meeting, register by March 16, 2005.

EPA's assessment of the noncancer health effects and carcinogenic potential of n-hexane was last prepared and added to the IRIS data base in 1990. The IRIS program is updating the IRIS assessment for n-hexane; this update will incorporate health effects information published since the last assessment was prepared as well as new risk assessment methods. The IRIS assessment for n-hexane will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physicochemical and toxicokinetic properties of the chemical and its toxicity in humans and experimental systems. The assessment will present reference values for noncancer effects of n-hexane (RfD and RfC) and a cancer assessment, where supported by available data. The Toxicological Review and IRIS Summary will be subject to internal peer consultation, Agency review, and external scientific peer review.

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