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Environmental Assessment

IRIS Toxicological Review of Trichloroacetic Acid (External Review Draft)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.

Report Information

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroacetic acid (TCA) that when finalized will appear on the Integrated Risk Information System (IRIS) database. Please refer to IRISTrack - Trichloroacetic acid for the latest schedule updates.

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Zheng (Jenny) Li
  • by phone at:   703-347-8577
  • by email at:  li.jenny@epa.gov


The draft Toxicological Review of trichloroacetic acid provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.


Mar 1996EPA posted the IRIS assessment for trichloroacetic acid on the IRIS database (cancer assessment only).
Sep 2009EPA released an external review draft for public review and comment. A public listening session to discuss the report will be held on November 4, 2009.
Sep 2009EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of Trichloroacetic Acid.
Nov 2009EPA announces the details of an external peer review workshop to be held on December 10, 2009 in a November 10, 2009 Federal Register Notice.
Jan 2010EPA releases the comments from the public comment period and external review workshop.

Next Steps

Following external peer review of the report, the final assessment will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA-HQ-ORD-2009-0203 (for the docket ID).


U.S. EPA. IRIS Toxicological Review of Trichloroacetic Acid (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/003A, 2009.


This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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