IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)
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Abstract
The draft Toxicological Review of trichloroacetic acid provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination. This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Mar 1996 | EPA posted the IRIS assessment for trichloroacetic acid on the IRIS database (cancer assessment only). |
Sep 2009 | EPA released an external review draft for public review and comment. A public listening session to discuss the report will be held on November 4, 2009. |
Sep 2009 | EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of Trichloroacetic Acid. |
Nov 2009 | EPA announces the details of an external peer review workshop to be held on December 10, 2009 in a November 10, 2009 Federal Register Notice. |
Jan 2010 | EPA releases the comments from the public comment period and external review workshop. |
Additional Information
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Trichloroacetic Acid (External Review Draft) (PDF) (253 pp, 1 MB, about PDF)
- Charge to External Peer Reviewers (PDF) (2 pp, 24 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (70 pp, 347 KB, about PDF)