IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)

Overview
History
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Abstract

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroacetic acid (TCA) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

The draft Toxicological Review of trichloroacetic acid provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

Impact/Purpose

The draft Toxicological Review of trichloroacetic acid provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.

Status

Following external peer review of the report, the final assessment will be posted to the IRIS database.

Citation

U.S. EPA. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/003A, 2009.

History/Chronology

Date	Description
01-Mar 1996	EPA posted the IRIS assessment for trichloroacetic acid on the IRIS database (cancer assessment only).
02-Sep 2009	EPA released an external review draft for public review and comment. A public listening session to discuss the report will be held on November 4, 2009.
03-Sep 2009	EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of Trichloroacetic Acid.
04-Nov 2009	EPA announces the details of an external peer review workshop to be held on December 10, 2009 in a November 10, 2009 Federal Register Notice.
05-Jan 2010	EPA releases the comments from the public comment period and external review workshop.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA-HQ-ORD-2009-0203 (for the docket ID).

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Toxicological Review of Trichloroacetic Acid (External Review Draft) (PDF) (253 pp, 1 MB, about PDF)
Charge to External Peer Reviewers (PDF) (2 pp, 24 KB, about PDF)
Consolidated Comments from the External Peer Review (Final) (PDF) (70 pp, 347 KB, about PDF)

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