IRIS Toxicological Review of Chloroprene (External Review Draft)

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Report Information

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of chloroprene that will appear on the Integrated Risk Information System (IRIS) database.

J. Allen Davis

by phone at: 919-541-3789
by fax at: 919-541-0245
by email at: davis.allen@epa.gov

Background

The draft Toxicological Review of chloroprene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to chloroprene. Chloroprene (C4H5Cl) is a volatile, flammable liquid used primarily in the manufacture of polychloroprene or neoprene rubber. The latter is used to make diverse products, such as tires, wire coatings, and tubing. Human health risk concerns for chloroprene are primarily related to exposures via effluent and emissions from facilities that use chloroprene to produce polychloroprene elastomers or transport the product, although these exposure concerns have not been well characterized.

This assessment contains the derivation of a chronic inhalation reference concentration (RfC) and chronic cancer inhalation unit risk.

History/Chronology

1999	The IRIS reassessment of chloroprene was initiated in 1999. Currently there is no entry in the IRIS database for chloroprene.
Sep 2009	EPA released the external review draft for public review and comment.
Nov 2009	EPA announced a public listening session to be held on November 23, 2009 in a November 5, 2009 Federal Register Notice.
Dec 2009	EPA announced an external peer review workshop to be held on January 6, 2010 in a December 1, 2009 Federal Register Notice.
Feb 2010	EPA released the comments from the public comment period and external review workshop.

Next Steps

Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the key word “EPA- HQ-ORD-2009-0217” (for the docket ID).

Citation

U.S. EPA. IRIS Toxicological Review of Chloroprene (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/010AF, 2009.

Downloads

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

IRIS Toxicological Review of Chloroprene (External Review Draft) (PDF) (185 pp, 909 KB, about PDF)
Charge to External Peer Reviewers (PDF) (3 pp, 13 KB, about PDF)
Consolidated Comments from the External Peer Review (Final) (PDF) (69 pp, 314 KB, about PDF)