Summary of the U.S. EPA Colloquium on a Framework for Human Health Risk Assessment (Volume 2, 1998)
The U.S. Environmental Protection Agency (EPA) has recognized the need to develop a framework for human health risk assessment that puts a perspective on the approaches in practice throughout the Agency. The framework will be a communication piece that will lay out the scientific basis, principles, and policy choices underlying past and current risk assessment approaches and will provide recommendations for integrating/harmonizing risk assessment methodologies for all human health endpoints. As an initial step in this process, the Agency's Risk Assessment Forum organized a colloquium series, consisting of two internal colloquia. The colloquia brought together EPA scientists for a dialogue on various scientific and policy issues pertaining to EPA's cancer and noncancer risk assessment approaches.
The second colloquium, held on June 2 and 3, 1998 in Bethesda, Maryland, explored the more quantitative aspects of mode of action, including dosimetry, dose-response relationships, and low-dose extrapolation methods. The present document summarizes discussions held during this colloquium. (See "Related Entries" for a summary report of the first colloquium held in 1997.)
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