Development and Peer Review of Time-to-Effect Models for the Analysis of Neurotoxicity and Other Time Dependent Data
The objective of this project is to provide Agency risk assessors with software tools that will facilitate the analysis of time dependent dose-response data. Data generated from neurobehavioral studies was used as example data during development of this software. The resultant statistical tools and models will be used by risk assessors both inside and outside of EPA. Anticipated products include new tools and models for incorporation into the Agency's benchmark dose software (BMDS) system, guidelines for the use of these models, and updates to BMDS web pages and user manuals.
- Polynomial Model for the Assessment of Time-Dependent Neurotoxicity Test Data
- Diffusion (PBPK) Model for the Assessment of Time-Dependent Neurotoxicity Test Data
- Guidelines for the Use of Models for the Assessment of Time-Dependent Neurotoxicity Data