Jump to main content or area navigation.

Contact Us

Environmental Assessment

Health Assessment Document for 1,2-Dichloroethane (Ethylene Dichloride). External Review Draft. Parts 1 and 2

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.


Report Information

Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indicate a concentration of equal to or less than 0.5 ppb for most locations. EDC is rapidly absorbed, metabolized, and eliminated. Unmetabolized EDC is eliminated almost exclusively via the lungs. In humans, the symptoms of acute toxicity from repeated exposures exceeding 60 ppm are irritation of the respiratory tract and eyes and CNS depression. According to available evidence EDC does not adversely affect the reproductive or development process in animals except at maternally toxic levels. Additional human epidemiologic studies are needed to establish conclusively that EDC is not a teratogen and does not cause adverse reproductive effects. Positive responses in different text systems indicate that EDC is a weak, direct-acting mutagen; however, several of its metabolites, formed in animals, are more potent mutagens than EDC. As a carcinogen, EDC induces tumors in rats and mice by various routes of exposure (gavage, intraperitoneally, dermally). However, lifetime inhalation exposure conditions did not produce tumors in rats or mice. Results from animal carcinogen studies, when considered with the positive evidence of mutagenicity and the presence of reactive metabolites and covalent bonding to DNA, suggest that EDC is a potential human carcinogen.

Jump to Table of Contents document
U.S. Environmental Protection Agency
Office of Reserach and Development
National Center for Environmental Assessment
Technical Information Staff
  • by phone at:   703-347-8561
  • by fax at:   703-347-8691
  • by email at:  nceadc.comment@epa.gov

Citation

Bosch, S., D. Gray, J. Santodonato, C. Chen, AND C. Miremath. Health Assessment Document for 1,2-Dichloroethane (Ethylene Dichloride). External Review Draft. Parts 1 and 2. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-84/006A (NTIS PB84209865), 1984.

Downloads

Jump to main content.