Health and Environmental Effects Profile for Phthalic Acid Esters
The report was prepared to support listings of hazardous constituents of a wide range of waste streams and to provide health-related limits for emergency actions. Published literature and information obtained from EPA program office files were evaluated as they pertained to potential human health, aquatic life and environmental effects of hazardous waste constituents. Quantitative estimates have been presented, provided sufficient data are available. D1(2-ethylhexyl)phthalate has been evaluated as a carcinogen and its human carcinogen potency factor for oral exposure was calculated. Diethyl phthalate and di-n-butyl phthalate have been determined to be systemic toxicants. Reference Doses (RfD), defined as an estimate of the daily exposure to the human population that is likely to be without appreciable risk of deleterious effect during a lifetime were estimated for oral exposure. Existing data are insufficient to determine an RfD or a carcinogenic potency factor for diisononyl phthalate, dimethyl phthalate, di-n-octyl phthalate and n-butyl benzyl phthalate. The Reportable Quantity value of 1, 10, 100, 1,000 or 5,000 pounds is used to determine the quantity of a hazardous substance for which notification is required in the event of a release.