Provisional Peer-Reviewed Toxicity Values for p-α,α,α-Tetrachlorotoluene
Provisional Peer-Reviewed Toxicity Value (PPRTV) assessments support the EPA mission to protect human health and the environment by identifying and characterizing the health hazards of chemicals of concern to the Superfund and RCRA Programs, and providing an important source of toxicity information and toxicity values for such chemicals. PPRTVs [provisional oral reference doses (p-RfDs), inhalation reference concentrations (p-RfCs), cancer risk values, and screening values] are derived after a review of the relevant scientific literature and using Agency methodologies, practices, and guidance for the development of toxicity values. Other EPA programs or external parties who choose of their own initiative to use PPRTV values are advised that Superfund resources will not be used to respond to challenges of these PPRTVs used in a context outside of the EPA Superfund Program.
Impact/Purpose
A Provisional Peer-Reviewed Toxicity Value (PPRTV) is defined as a toxicity value derived for use in the Superfund Program. PPRTVs are derived after a review of the relevant scientific literature using established Agency guidance on human health toxicity value derivations. All PPRTV assessments receive internal review by at least two Center for Public Health and Environment Assessment (CPHEA) scientists and an independent external peer review by at least three scientific experts.
Citation
U.S. EPA. Provisional Peer-Reviewed Toxicity Values for p-α,α,α-Tetrachlorotoluene. U.S. Environmental Protection Agency, Washington, DC, EPA/690/R-19/002F, 2019.
History/Chronology
| Date | Description |
|---|---|
| Sep 2019 | EPA finalized and delivered the assessment to the Superfund Program. Subchronic and chronic provisional RfDs, subchronic and chronic provisional RfCs, and a provisional oral slope factor were derived and this is the first entry of this chemical into the PPRTV collection. |
| Nov 2019 | EPA published the final report and values on the PPRTV website. |
| Apr 2020 | EPA released an errata sheet about a formatting update. |
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.