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Environmental Assessment

Advancing the Next Generation of Health Risk Assessment

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Over the past 20 years, knowledge of the genome and its function has increased dramatically, but risk assessment methodologies utilizing such knowledge have not advanced accordingly.

Objective. This review describes a collaborative effort among several federal and state agencies to advance the next generation of risk assessment. The objective of the NexGen program is to begin to incorporate recent progress in molecular and systems biology into risk assessment practice. The ultimate success of this program will be based on the incorporation of new practices that facilitate faster, cheaper, and/or more accurate assessments of public health risks. Methods. We are developing prototype risk assessments that compare the results of traditional, data-rich risk assessments with insights gained from new types of molecular and systems biology data. In this manner, new approaches can be validated, traditional approaches improved, and the value of different types of new scientific information better understood.

Discussion and Conclusions. We anticipate that these new approaches will have a variety of applications, such as assessment of new and existing chemicals in commerce and the design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Additionally, results of the effort are likely to spur further research and test methods development. Full implementation of new approaches is likely to take 10 to 20 years.

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Ila L. Cote
  • by phone at:   303-312-6927
  • by email at:  cote.ila@epa.gov

Citation

COTE, I. L., P. T. ANASTAS, L. S. BIRNBAUM, B. A. CLARK, D. J. DIX, S. W. EDWARDS, AND P. W. PREUSS. Advancing the Next Generation of Health Risk Assessment. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 120(11):1499-1502, (2013).

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