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Environmental Assessment

IRIS Toxicological Review of Tetrahydrofuran (THF) (Interagency Science Discussion Draft)

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Report Information

EPA is releasing the draft report, Toxicological Review of Tetrahydrofuran, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

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Norman Birchfield
  • by phone at:   703-347-0174
  • by fax at:   703-347-8699
  • by email at:  birchfield.norman@epa.gov


The draft Toxicological Review of Tetrahydrofuran provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to tetrahydrofuran. Tetrahydrofuran, or THF, is used as a solvent for polyvinyl chlorides, vinylidene chloride polymers, natural and synthetic resins (particularly vinyls), in topcoating solutions, polymer coatings, cellophane, protective coatings, adhesives, magnetic strips and printing inks. It is also used for Grignard and metal hydride reactions. THF is used as an intermediate in chemical synthesis. For example, it is used in the preparation of chemicals including adipic acid, butadiene, acrylic acid, butylrolactone, succinic acid, 1,4-butanediol diacetate, motor fuels, vitamins, hormones, pharmaceuticals, synthetic perfumes, organometallic compounds, and insecticides. It is also used in the manufacture of polytetramethylene ether glycol, polyurethane elastomers, and elastic polymers. THF can be used in the fabrication of materials for food packaging, transport, and storage.


Aug 2007EPA releases the first External Review Draft for public review and comment. EPA announced the external peer review meeting to be held on November 1, 2007. [Federal Register Aug 20, 2007]
Sep 2011EPA hosted an interagency science discussion on the review of the draft Toxicological Review of THF.
Feb 2012EPA releases the final toxicological review and IRIS Summary for Tetrahydrofuran, along with the interagency science discussion draft, interagency comments, and EPA's response to major interagency comments.

Next Steps

This assessment has been loaded into the IRIS Web site and Database.


U.S. EPA. IRIS Toxicological Review of Tetrahydrofuran (THF) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/006D, 2011.


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