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Environmental Assessment

IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)

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Report Information

EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

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Norman Birchfield
  • by phone at:   703-347-0174
  • by fax at:   703-347-8699
  • by email at:  birchfield.norman@epa.gov

Background

The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.

History/Chronology

Aug 2009EPA hosted an interagency science consultation on the draft Toxicological Review of Trichloroacetic Acid.
Sep 2009EPA released an External Reviewer Draft for public comment. EPA also announced a public listening session on Nov 4, 2009 [Federal Register Sep 24, 2009]
Nov 2009EPA announced the external peer review meeting to be held on December 10, 2009. [Federal Register Nov 10, 2009]
Jan 2010EPA released the comments from the external review workshop.
Jul 2011EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Trichloroacetic Acid.
Sep 2011EPA releases the final toxicological review and IRIS Summary for Trichloroacetic Acid and the interagency science discussion draft with interagency comments.

Next Steps

This assessment has been loaded into the IRIS Web site and Database.

Citation

U.S. EPA. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/003D, 2011.

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