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Environmental Assessment

IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft, 2011)

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On September 8, 2011, the Toxicological Review of n-Butanol (External Review Draft) was released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments with EPA's response and the interagency science consultation draft of the IRIS Toxicological Review of n-Butanol and the charge to external peer reviewers are posted on this site.

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Norman Birchfield
  • by phone at:   703-347-0174
  • by fax at:   703-347-8699
  • by email at:  birchfield.norman@epa.gov


The draft Toxicological Review of n-butanol provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to n-butanol. n-Butanol is widely used as an organic solvent and is an intermediate in the manufacture of other organic chemicals such as acetates, acrylates and glycol ethers. n-Butanol is also a natural component of many foods and formed during the fermentation of carbohydrates.


Mar 1987A RfD was posted for n-butanol to the IRIS Database.
Mar 1991The cancer assessment for n-butanol was posted to the IRIS Database.
Jun 2011EPA initiated the interagency science consultation on the draft Toxicological Review of n-Butanol.
Sep 2011EPA released the External Review Draft for public review and comment.

Next Steps

Following external peer review the assessment will be revised taking into consideration external peer review and public comments. The revised assessment will undergo a final EPA internal review and review by other federal agencies and White House offices, then the final assessment will be posted to the IRIS database.


U.S. EPA. IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft, 2011). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/081C, 2011.


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