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Environmental Assessment

IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft)


EPA announces the release of the Toxicological Review of Vanadium Pentoxide in a September 30, 2011 Federal Register Notice. This draft assessment is provided for public viewing and comment. An independent public peer review meeting has been scheduled for March 7, 2012 as announced in a February 6, 2012 Federal Register Notice.

Report Information

This vanadium pentoxide reassessment consists of an oral reference dose (RfD), an inhalation reference concentration (RfC), an inhalation unit risk (IUR) and a cancer weight of evidence descriptor. This is the first assessment developing an RfC or IUR for this compound. This assessment is intended to provide human health data to support agency regulatory decisions. Please refer to IRISTrack - Vanadium Pentoxide for the latest schedule updates.

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Maureen R. Gwinn
  • by phone at:   703-347-8565
  • by fax at:   703-347-8692
  • by email at:  gwinn.maureen@epa.gov


Vanadium pentoxide is the most common commercial form of vanadium. It is used as a catalyst in the production of sulfuric acid and some nanomaterials. When fuel oils containing vanadium are combusted, they leave behind byproducts containing vanadium pentoxide in the forms of dust, soot, boiler scale, and fly ash. Vanadium is found at multiple Superfund sites.


Jan 1987The RfD for vanadium pentoxide was posted to the IRIS Database.
Sep 2011EPA hosted an interagency science consultation on the review of the draft Toxicological Review of Vanadium Pentoxide.
Sep 2011EPA released the external review draft of the vanadium pentoxide assessment for public review and comment. [Federal Register Notice Sep 30, 2011]
Nov 2011EPA extended the deadline for comments until December 29, 2011 to allow reviewers more time. The originally scheduled public listening session was also re-scheduled to December 8, 2011. [Federal Register Notice Nov 9, 2011]
Feb 2012EPA announced the independent public peer review meeting to be held in Arlington, VA on March 7, 2012. [Federal Register Notice Feb 6, 2012]
May 2012EPA released the comments from the public comment period and external review workshop.

Next Steps

Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA-HQ-ORD-2011-0738 (for the docket ID).


U.S. EPA. IRIS Toxicological Review of Vanadium Pentoxide (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/004A, 2011.


This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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