IRIS Toxicological Review for Acrylamide (Interagency Science Discussion Draft)
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EPA is releasing the draft report, Toxicological Review for Acrylamide, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.
Acrylamide is a chemical used in the production of polyacrylamide polymers. Polyacrylamides are used as a flocculent in water purification, oil recovery, and soil conditioning and stabilization. Other uses include paper making, adhesion-promotion, dye acceptors, and textile additives. Human exposure to acrylamide had been thought to occur primarily in the workplace from dermal contact and inhalation of dust and vapor, with the general public being potentially exposed to low levels of acrylamide primarily through contaminated drinking water.
In addition, the draft toxicological review notes that cigarette smoke (direct and secondary) is another exposure route. In early 2002, Swedish scientists reported high concentrations of acrylamide in certain fried, baked, and deep-fried foods. Subsequent research demonstrated that acrylamide forms de novo during processing of some foods, especially during high temperature cooking of carbohydrate-rich foods that contain asparagine.
This assessment contains the derivation of a chronic reference dose (RfD) and a chronic reference concentration (RfC) for non-cancer effects, as well as an oral slope factor and an inhalation unit risk for carcinogenic effects.
|Nov 2007||EPA releases the external review draft for public review. [Federal Register Dec 28, 2007]|
|Feb 2008||SAB announces 2 external peer review meetings (first a public teleconference to be held on Feb 20, 2008 , and second a face-to-face meeting March 10 -12, 2008). [Federal Register Notice Feb 1, 2008]|
|Dec 2008||SAB finalizes their review report of the Toxicological Review of Acrylamide.|
|Feb 2010||EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Acrylamide.|
|Mar 2010||EPA released the comments from the external review workshop.|
|Mar 2010||EPA released the final Toxicological Review and IRIS Summary for Acrylamide and the interagency review draft with interagency review comments.|