IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft, 2010)
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
Then in 2014, EPA began revising its assessment to address the 2011 NAS peer review recommendations (see related links). This assessment addresses both noncancer and cancer human health effects that are relevant to assessing the risks from chronic inhalation exposure to formaldehyde. To facilitate discussion of several scientific issues pertinent to the assessment, EPA convened a public workshop held on April 30 and May 1, 2014. This workshop focused on the following three themes:
- Evidence pertaining to the influence of formaldehyde that is produced endogenously (by the body during normal biological processes) on the toxicity of inhaled formaldehyde, and implications for the health assessment;
- Mechanistic evidence relevant to formaldehyde inhalation exposure and lymphohematopoietic cancers (leukemia and lymphomas); and
- Epidemiological research examining the potential association between formaldehyde exposure and lymphohematopoietic cancers (leukemia and lymphomas).
The draft toxicological review of formaldehyde - inhalation assessment provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic inhalation exposure to formaldehyde. Formaldehyde is present in a wide variety of products including some plywood adhesives, abrasive materials, insulation, insecticides and embalming fluids. The major sources of anthropogenic emissions of formaldehyde are motor vehicle exhaust, power plants, manufacturing plants that produce or use formaldehyde or substances that contain it (i.e. glues), petroleum refineries, coking operations, incinerating, wood burning and tobacco smoke.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Sep 1990 | The oral RfD for formaldehyde was posted to the IRIS database. |
May 1991 | The cancer assessment for formaldehyde was posted to the IRIS database. |
Jan 1998 | EPA begins the formaldehyde reassessment under the IRIS Program. |
May 2010 | EPA initiated an interagency science consultation on the review of the draft Toxicological Review of formaldehyde. |
Jun 2010 | EPA released an external review draft of the formaldehyde reassessment for public review and comment. Also released was the interagency review draft with comments. |
Jun 2010 | On Jun 7-8, 2010 in Washington DC, EPA conducted an independent expert peer review by the National Academy of Sciences and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Formaldehyde-Inhalation that when finalized will appear on the Integrated Risk Information System (IRIS) database. This draft IRIS health assessment addresses both noncancer and cancer human health effects that may result from chronic inhalation exposure to this chemical. |
Jul 2010 | NAS held their second external review meeting to discuss the draft report on July 6, 2010. |
Aug 2010 | NAS held their third external review meeting to discuss the draft report on Aug 9-10, 2010 in Washington, DC. |
Oct 2010 | NAS held their fourth external review meeting to discuss the draft report on Oct 12-13, 2010 in Washington, DC. |
Dec 2010 | NAS held their fifth and final external review meeting to discuss the draft report on Dec 13-14, 2010 in Los Angelos, CA. |
May 2011 | NAS's Board on Environmental Studies and Toxicology (BEST) releases the NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report). |
Additional Information
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Formaldehyde-Inhalation Assessment: In Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF) (1043 pp, 8 MB, about PDF)
- Tox Review of Formaldehyde, Volume 1: Introduction, Background, and Toxicokinetics (PDF) (112 pp, 1 MB, about PDF)
- Tox Review of Formaldehyde, Volume 2: Hazard Characterization (PDF) (570 pp, 4 MB, about PDF)
- Tox Review of Formaldehyde, Volume 3: Quantitative Assessment, Major Conclusions in the Characterization of Hazard and Dose Response, and References (PDF) (253 pp, 2 MB, about PDF)
- Tox Review of Formaldehyde, Volume 4: Appendices (PDF) (108 pp, 1 MB, about PDF)
- Charge to the NAS Panel (PDF) (2 pp, 24 KB, about PDF)
- Agency Response to Formaldehyde 2010 ERD (PDF) (NA pp, 29 KB, about PDF)
Related Link(s)
- NAS: Review of EPA's Draft IRIS Assessment of Formaldehyde (Project Overview)
- NAS Public Review Mtg Announcement: Jun 7-8, 2010
- Press Release: EPA Releases Draft Formaldehyde Assessment Report for Peer Review and Public Comment
- NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report)
- IRIS Toxicological Review of Formaldehyde (Interagency Science Consultation Draft, 2010)
- IRIS Program Outlook April 2019-Suspended/Discontinued Assessment