Environmental Assessment
Benchmark Dose Technical Guidance Document (External Review Draft)
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Report Information
The purpose of this document is to provide guidance for the Agency on the application of the benchmark dose approach in determining the point of departure (POD) for health effects data, whether a linear or nonlinear low dose extrapolation is used. The guidance includes discussion on computation of benchmark doses and benchmark concentrations (BMDs and BMCs) and their lower confidence limits, data requirements, dose-response analysis, and reporting requirements. This guidance is based on today's knowledge and understanding, and on experience gained in using this approach.
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Downloads
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Benchmark Dose Technical Guidance Document (External Review Draft) (PDF) (96 pp, 830 KB, about PDF)
- Logistical Fact Sheet (PDF) (3 pp, 18 KB, about PDF)
- Peer Review Workshop Documents - Charge to Reviewers (PDF) (2 pp, 8 KB, about PDF)