IRIS Toxicological Review of 1,4-Dioxane (2010 Final)
EPA announces the release of the final report, Toxicological Review of 1,4-Dioxane (CAS No. 123-91-1): In Support of Summary Information on the Integrated Risk Information System (IRIS).
The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.
|Aug 1988||EPA released the assessment for 1,4-Dioxane.|
|Oct 2003||The IRIS reassessment of 1,4-dioxane was started.|
|May 2009||EPA released an external review draft for public review and comment.|
|Sep 2009||EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.|
|Aug 2010||EPA releases the final report and the interagency review draft with comments.|
- (319 pp, 4 MB, about PDF)