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Environmental Assessment

IRIS Toxicological Review of 1,4-Dioxane (2010 Final)


EPA announces the release of the final report, Toxicological Review of 1,4-Dioxane (CAS No. 123-91-1): In Support of Summary Information on the Integrated Risk Information System (IRIS).

Report Information

The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

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Eva Mclanahan
  • by phone at:   919-541-1396
  • by fax at:   919-541-0245
  • by email at:  mclanahan.eva@epa.gov


Aug 1988EPA released the assessment for 1,4-Dioxane.
Oct 2003The IRIS reassessment of 1,4-dioxane was started.
May 2009EPA released an external review draft for public review and comment.
Sep 2009EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.
Aug 2010EPA releases the final report and the interagency review draft with comments.


U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (2010 Final). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/005F, 2010.


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