Environmental Assessment
IRIS Toxicological Review of 1,4-Dioxane (2010 Final)
Notice
EPA announces the release of the final report, Toxicological Review of 1,4-Dioxane (CAS No. 123-91-1): In Support of Summary Information on the Integrated Risk Information System (IRIS).
Report Information
The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.
- by phone at: 919-541-1396
- by fax at: 919-541-0245
- by email at: mclanahan.eva@epa.gov
History/Chronology
| Aug 1988 | EPA released the assessment for 1,4-Dioxane. |
| Oct 2003 | The IRIS reassessment of 1,4-dioxane was started. |
| May 2009 | EPA released an external review draft for public review and comment. |
| Sep 2009 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane. |
| Aug 2010 | EPA releases the final report and the interagency review draft with comments. |