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IRIS Toxicological Review of Pentachlorophenol (External Review Draft)

Federal Register Notices
Contact
Catherine Gibbons
by phone at:   703-603-0704
by email at:  gibbons.catherine@epa.gov
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Notice

EPA announces the release of the Toxicological Review of Pentachlorophenol in a May 7, 2009 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within 60 days after the release of the FRN will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions. The date and location of the external peer review meeting will be provided in a separate announcement.

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of pentachlorophenol that will appear in the Integrated Risk Information System (IRIS) database.
Background
The draft Toxicological Review of Pentachlorophenol provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to pentachlorophenol. Pentachlorophenol is a wood preservative used to prevent decay from fungal organisms and insect damage. Use by the public was restricted in 1984, and application was limited to industrial areas. It has been reported in food, surface water, groundwater, rainwater, and soil. People who work or reside in close proximity to wood treatment facilities, treated lumber, or hazardous waste sites are likely exposed.

This assessment contains a revised oral reference dose (RfD) for chronic noncancer health effects as well as a revised oral cancer risk estimate.

History/Chronology

Jan 1987EPA posted the pentachlorophenol assessment on the IRIS database (RfD only).
Mar 1991EPA posted the carcinogenicity assessment for oral exposure to pentachlorophenol on the IRIS database.
May 2009EPA released an updated draft report for public review and comment.
Jun 2009EPA announced a public listening session for the draft review report.
Jun 2009EPA announced a external peer review meeting to be held August 4th in Arlington, VA.
Oct 2009EPA releases the comments from the public comment period and external review workshop.

Next Steps

Following the External Peer Review, the final assessment will be published on the IRIS database.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2009-0178 (for the docket ID) to comment on this report.

Citation

U.S. EPA. IRIS Toxicological Review of Pentachlorophenol (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/004.
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