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Environmental Assessment

IRIS Toxicological Review and Summary Documents for Chloroform (Final Report)

Report Information

EPA is announcing the release of the final report, Toxicological Review of Chloroform: in support of the Integrated Risk Information System (IRIS). The updated Summary for Chloroform and accompanying Quickview have also been added to the IRIS Database.

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Zheng (Jenny) Li
  • by phone at:   703-347-8577
  • by email at:  li.jenny@epa.gov


Chloroform (trichloromethane) is a colorless, volatile liquid with a distinct odor. Chloroform is nonflammable. It is slightly soluble in water and is readily miscible with most organic solvents. Because chloroform is relatively volatile, it tends to escape from contaminated environmental media (e.g., water or soil) into air, and may also be released in vapor form from some types of industrial or chemical operations. Therefore, humans may be exposed to chloroform not only by ingestion of chloroform in drinking water, food, or soil, but also by dermal contact with contaminated media (especially water) and by inhalation of vapor (especially in indoor air).


October 2001EPA released the final tox report and summary document and posted these to the IRIS database.


U.S. EPA. IRIS Toxicological Review and Summary Documents for Chloroform (Final Report). U.S. Environmental Protection Agency, Washington, DC, 2001.


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