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2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Dose-Response Studies: Preliminary Literature Search Results and Request for Additional Studies

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EPA invited the public to comment on the preliminary list of in vivo mammalian dose-response citations for 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD). This list was compiled as a first step in the development of EPA’s response to the National Academy of Sciences comments (NAS, 2006) on the dose-response assessment presented in the Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds (Dioxin Reassessment, EPA, 2003).

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Annette M. Gatchett
  • by phone at:   513-569-7531
  • by fax at:   513-569-7475
  • by email at:  gatchett.annette@epa.gov

Background

The primary objective of the literature search from which this preliminary list is based was to identify peer-reviewed in vivo mammalian dose-response studies for TCDD that have been published since the Dioxin Reassessment (EPA, 2003). This includes in vivo mammalian dose-response of TCDD and epidemiological studies of TCDD. The literature search was conducted using the online National Library of Medicine database, PubMed, and focused on identifying studies published between the year 2000 and October 31, 2008. The literature search was conducted by the U.S. Department of Energy’s Argonne National Laboratory through an Interagency Agreement with the EPA. The literature search strategy explicitly excluded studies addressing: (1) analytical/detection data and cellular screening assays; (2) environmental fate and concentration data; (3) dioxin-like compounds and toxic equivalents; (4) non-mammalian dose-response data; (5) human exposure analyses only, including body burden data; and (6) combustor or incinerator or other facility-related assessments absent primary dose-response data. The EPA is not seeking submissions or comments on these types of studies at this time.

The EPA invites your review of this preliminary list of in vivo mammalian dose-response citations for TCDD. At this time the Agency requests that interested parties submit only peer-reviewed, in vivo mammalian dose-response studies for TCDD including epidemiological studies that are absent from this list. The EPA asks that the inputs include full citations and the full publication. Directions for submitting these additional studies for the Agency’s consideration are provided below. These submissions will be used during the conduct of a scientific expert workshop on TCDD dose-response modeling, open to the public, to be held in Cincinnati, Ohio on February 18-20, 2009 (to be announced in a future Federal Register Notice).

Two additional citation lists are being provided here for convenience. First, the EPA is providing a list of citations relevant to dose-response assessment that were published in Part II (all citations) and Part III of the 2003 draft Dioxin Reassessment (all citations). Second, the EPA also is providing a preliminary list of supporting references published since the release of the 2003 Dioxin Reassessment pertaining to studies of TCDD kinetic data, TCDD mode-of-action, in vitro TCDD studies, and TCDD risk assessment approaches. The EPA is not seeking the submission of additional studies or comments on these types of studies or these two lists at this time.

History/Chronology

Next Steps

An expert workshop on TCDD dose-response modeling, open to the public, to be held in Cincinnati, Ohio on February 18-20, 2009 (to be announced in a future Federal Register Notice).

Additional Information

Comments on this prelimary list may be submitted and reviewed using the e-Government Regulations.gov web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2008-0789 (for the docket ID).

Citation

U.S. EPA. 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Dose-Response Studies: Preliminary Literature Search Results and Request for Additional Studies. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-08/119, 2008.

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