Measurement Error Estimation and Correction Methods to Minimize Exposure Misclassification in Epidemiological Studies: Project Summary
This project summary highlights recent findings from research undertaken to develop improved methods to assess potential human health risks related to drinking water disinfection byproduct (DBP) exposures.
This report summarizes some of the recent progress in this area that has been conducted by the National Center for Environmental Assessment (NCEA). The primary objective of this research was to examine the utility of routinely collected monitoring data to estimate individual-level exposures in epidemiological studies. Another specific aim was to estimate the potential for exposure misclassification bias due to a variety of sources including (1) unmeasured spatial variability in town average surrogate measures and (2) lack of integration of individual water use practices data including exposure-modifying factors. In addition to quantifying potential exposure misclassification bias, we developed an approach to correct for measurement error that may cause this bias. This research provides valuable information to the risk assessment community in their efforts to quantify the potential impact of using indirect exposure assessment metrics in epidemiologic studies.
|May 2005||Manuscript published on examination of misclassification bias from spatial variability.|
|Jul 2006||Manuscript published on examination of misclassification bias from inter-individual variability.|
|Sep 2008||Manuscript submitted on development of an approach to correct for measurement error.|
|Sep 2008||Completion of EPA Summary Report on Measurement Error Estimation and Correction Methods to Minimize Exposure Misclassification in Epidemiological Studies.|
Bateson T.F. and J.M. Wright. 2007. Regression calibration to ameliorate classical measurement error bias in disinfection by-product studies. Am. J. Epidemiol. 165(Suppl):S37.
Wright J.M. and T.F. Bateson. 2005. A sensitivity analysis of bias in relative risk estimates due to disinfection by-product exposure misclassification. J. Expos. Anal. Environ. Epidem. 15:212–216.
Wright J.M., P.A. Murphy, M.J. Nieuwenhuijsen and D.A. Savitz. 2006. The impact of water consumption, point-of-use filtration and exposure categorization on exposure misclassification of ingested drinking water contaminants. Sci. Total Environ. 366:65–73.