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Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (External Review Draft)
Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.
Federal Register Notices
Contact
- Lynn Flowers
- by phone at: 703-347-8537
- by email at: flowers.lynn@epa.gov
Notice
[12/08] EPA released this draft report as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. Comments from the independant external peer review are now available.
EPA released this document in draft form as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. The document has since been revised, final report, in response to comments from independent external peer review. A copy of the PBPK model code is available. In addition, the final peer review report and a summary of external peer review comments and EPA responses are available.Background
This report provides an analysis of perchlorate-mediated inhibition of the sodium-iodide symporter (NIS) in humans using published PBPK models, focusing on the degree of NIS inhibition as a function of lifestage. The models provide information that may be used to address differences in human responses to perchlorate across lifestages.
History/Chronology
| Oct 2008 | EPA released an external review draft for public review and comment as a supporting document to the EPA Drinking Water Ruling. |
| Dec 2008 | EPA released the consolidated comments from the independent external peer review. |
| Aug 2009 | EPA released the summary of external peer review comments and disposition for the 2008 external review draft of the report with the draft report. |
| Aug 2009 | EPA publishes the final report. |
Next Steps
Following the external peer review, EPA plans to release a revised final document.
Downloads/Related Links
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (External Review Draft) (PDF) (68 pp, 14 MB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (145 pp, 1 MB, about PDF)
- Summary of External Peer Review Comments and Disposition for the 2008 external review draft of the report Inhibition of the Sodium-Iodide Symporter by Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically-based Pharmacokinetic (PBPK) Modeling (PDF) (34 pp, 288 KB, about PDF)
Citation
U.S. EPA. Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (External Review Draft). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/R-08/106A, 2008.
