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IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (External Review Draft)

Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.

Federal Register Notices
Contact
Martin Gehlhaus
by phone at:   703-347-8579
by email at:  gehlhaus.martin@epa.gov
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Notice

[09/25/09] UPDATE: As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the cerium oxide and cerium compounds IRIS assessment will be available on this website on or before October 14, 2009.

[05/06/07] EPA announces the release of the Toxicological Review of cerium oxide and cerium compounds and notice of the External Peer Review Panel Meeting in the May 6, 2007 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review during the public comment period will be provided to the external peer reviewers for their consideration during the External Peer Review Panel Meeting. Any comments not received within the requested time period will be considered by EPA in their revisions.

EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of cerium oxide and cerium compounds that will appear on the Integrated Risk Information System (IRIS) database.
Background
The draft Toxicological Review of cerium oxide and cerium compounds provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cerium oxide and cerium compounds. Cerium oxide is a polishing agent for glass mirrors, plate glass, television tubes, ophthalmic lenses, and precision optics, and is also used in emission control systems in gasoline engines and as a diesel fuel-born catalyst to reduce particulate matter emissions. Cerium is most heavily used in the form of mischmetal, a commercial mixture of metallic light lanthanides, for metallurgical purposes.

This assessment contains the derivation of a chronic reference concentration and a cancer characterization.

History/Chronology

2005EPA began reviewing the Tox Assessment of cerium oxide and cerium compounds.
May 2007EPA announces the external peer review panel meeting in a May 6, 2007 Federal Register Notice.
May 2008EPA releases the draft document for an external peer review.
Sep 2009EPA released the Final Toxicological Review (PDF) (118 pp, 703K) and accompanying Summary for Cerium Oxides to the IRIS Web site.

Next Steps

Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Related Link(s)

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2008-0111 (for the docket ID).

Citation

U.S. EPA. IRIS Toxicological Review of Cerium Oxide and Cerium Compounds (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/002A.
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