IRIS Toxicological Review of Beryllium and Compounds (2008 External Review Draft)

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Report Information

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Beryllium that when finalized will appear on the Integrated Risk Information System (IRIS) database. Please refer to IRISTrack - Beryllium for the latest schedule updates.

Amanda Persad

by phone at: 919-541-9781
by fax at: 919-541-2985
by email at: persad.amanda@epa.gov

Background

Beryllium is a light alkaline earth metal used in metal alloys and in high-performance products in the metallurgical, aerospace, and nuclear industries. According to the Superfund database, beryllium is found in over 300 NPL sites. An IRIS Toxicological Review of Beryllium and Compounds was published in 1988 and reassessed in 1998.

This external review draft version only focuses on the cancer assessment and does not re-evaluate posted reference doses or reference concentrations.

History/Chronology

Nov 1987	EPA completed the original beryllium and compounds assessment and posted this in the IRIS database.
Apr 1998	Reassessment of oral reference dose and inhalation reference concentration released with cancer reassessment pending forthcoming studies.
May 2008	EPA releases assessment that includes updated draft cancer assessment for an external peer review.

Next Steps

This draft has been archived.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2008-0315 (for the docket ID).

Citation

U.S. EPA. IRIS Toxicological Review of Beryllium and Compounds (2008 External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/009A, 2008.

Downloads

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Toxicological Review of Beryllium (External Review Draft) (PDF) (144 pp, 631 KB, about PDF)
Charge to External Peer Reviewers (PDF) (2 pp, 19 KB, about PDF)
Consolidated Comments from the External Peer Review (Final) (PDF) (35 pp, 292 KB, about PDF)