Jump to main content.

IRIS Toxicological Review of 2-Hexanone (External Review Draft)

Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.

Federal Register Notices
Contact
Amanda Persad
by phone at:   919-541-9781
by fax at:   919-541-2985
by email at:  persad.amanda@epa.gov
Go To Downloads

Notice

[09/25/09] UPDATE: As per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the 2-Hexanone IRIS assessment will be available on this website on or before October 14, 2009.

[04/23/08] EPA announced the External Peer Review Meeting to be held on May 22, 2008 in an April 23, 2008 Federal Register Notice.

[03/03/08] EPA announced the release of the Toxicological Review of 2-Hexanone in the March 3, 2008 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within the external review period (next 60 days) will be provided to the external peer reviewers prior to the meeting for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions.

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 2-hexanone that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
Background
2-Hexanone was nominated for IRIS assessment because of its frequent detection at sites nationwide and its occurrence as a byproduct of certain industrial processes. 2-Hexanone has been used as a solvent for lacquers, ink thinners, nitrocellulose, resins, oils, fats and waxes. The only U.S. producer of 2-hexanone, the Tennessee Eastman Company division of Eastman Kodak, discontinued its production of 2-hexanone in 1979 and sold its remaining reserves by 1981.

History/Chronology

Jan 2008EPA completes the Interagency Review of the 2-hexanone Toxicological Risk Assessment.
Feb 2008EPA releases the first assessment of 2-hexanone in the IRIS database for public comment and review in preparation for an External Peer Review.
Mar 2008EPA released the external review draft for the Toxicological Review of 2-Hexane.
May 2008An external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of 2-Hexanone (External Review Draft).
Sep 2009EPA released the Final Toxicological Review (PDF) (136 pp, 964K) and accompanying Summary for 2-Hexanone to the IRIS Web site.

Next Steps

Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Related Link(s)

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2008-0048 (for the docket ID).

Citation

U.S. EPA. IRIS Toxicological Review of 2-Hexanone (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, NCEA-S-2764, 2008.
Email a link to this page to a friend

ORD Home | Search EPA

Local Navigation

Jump to main content.