IRIS Toxicological Review of Thallium and Compounds (External Review Draft)
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Thallium compounds are used in the semiconductor industry, the manufacture of optic lenses and low-melting glass, low-temperature thermometers, alloys, electronic devices, mercury lamps, fireworks, and imitation germs, and clinically as an imaging agent in the diagnosis of certain tumors. EPA's assessment of noncancer health effects and carcinogenic potential of thallium compounds was last prepared and added to the IRIS database between 1988 and 1990. The IRIS program is preparing an assessment that will incorporate current health effects information available for thallium and compounds, and current risk assessment methods. The IRIS assessment for thallium compounds will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physiochemical and toxicokinetic properties of a chemical, and its toxicity in humans and experimental systems. The assessment will present reference values for the noncancer effects of thallium compounds (RfD and Rfc), and a cancer assessment. The Toxicological Review and IRIS Summary have been subject to Agency review, Interagency review, and external scientific peer review. The final product will reflect the Agency opinion on the overall toxicity of thallium and compounds.
|1987||IRIS assessments of thallium acetate, carbonate, chloride, nitrate, selenite, and sulfate, and thallic oxide posted on the IRIS database (RfD only).|
|1988||RfDs for thallium compounds revised.|
|1989||RfD for thallic oxide withdrawn from the IRIS database.|
|1990||Carcinogenicity assessments for thallium compounds added to the IRIS database.|
|1993||RfD for thallium selenite withdrawn from the IRIS database.|
|Feb 2008||EPA releases the draft document, IRIS Toxicological Review of Thallium, for public review and comment in a February 15, 2008 Federal Register notice.|
|Apr 2008||EPA announces the external peer review panel workshop in an April 8, 2008 Federal Register notice.|
|Sep 2009||EPA released the Final Toxicological Review (PDF) (136 pp, 964K) and accompanying Summary for Thallium and Compounds to the IRIS Web site.|
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