Environmental Assessment
IRIS Agenda and Literature Searches
Notice
[Jul 2012] EPA posted the literature search for benzo[a]pyrene in anticipation of starting a draft assessment and is soliciting scientific information on health effects that may result from exposure to this chemical substance. EPA will accept information related to the specific substance included herein as well as any other compound being assessed by the IRIS Program. [Federal Register Notice Jul 16, 2012]
[Jun 2012] EPA posted the literature search for acrylonitrile (CAS No. 107-13-1) and is requesting scientific information on health effects that may result from exposure to this chemical substance.
[May 2012] EPA is announced the 2012 IRIS agenda in the Federal Register and is requesting scientific information on health effects that may result from exposure to the chemical substances on the agenda, including any assessments that EPA has started this year. [Federal Register Notice May 7, 2012]
Report Information
IRIS is an EPA database of human health effects that may result from exposure to chemical substances found in the environment. EPA's process for developing IRIS assessments is described in detail on the IRIS Process Web page.
IRIS Agenda
[UPDATE] EPA is announcing the IRIS 2012 agenda and requesting scientific information on health effects that may result from exposure to the chemical substances on the agenda, including assessments that EPA is starting this year. Full details of the IRIS Agenda is posted in the federal register. [Federal Register Notice May 7, 2012]
See the history section (below) for a list of previous IRIS Agenda announcements in the Federal Register.
IRIS Literature Searches
Since December 2007, EPA has actively solicited information from the public at the beginning of assessment development. As literature searches are completed, the results are posted here. All available literature searches are listed in the table below. The public is invited to review the literature search results and submit additional information to EPA through the regulations.gov web site. Instructions for submitting information are given below. Then, based on the results of the literature searches and as EPA resources allow, assessments will be started for those chemicals with data that may support development of one or more toxicity values. For a list of chemical currently under development, see IRISTrack.| Substance | Literature Search Reports (Click PDF Links) |
# Pages | Released |
|---|---|---|---|
| Acetaldehyde (CAS No. 75-07-0) |  |
31 |
4/12 |
| Acrylonitrile (CAS No. 107-13-1) | |
69 |
6/12 |
| Ammonia (CAS No. 7664-41-7) | |
33 |
11/09 |
| Benzo[a]pyrene (CAS No. 50-32-8) | |
80 |
7/12 |
| Biphenyl (CAS No. 92-52-4) | |
55 |
12/07 |
| Carbonyl Sulfide (CAS No. 463-58-1) | |
113 |
12/07 |
| Cobalt and Inorganic Cobalt Compounds (CAS No. 7440-48-4 and various) |
|
38 |
3/11 |
| Cyclohexane* (CAS No. 110-82-7) | |
22 |
11/09 |
| Diethyl Phthalate (CAS No. 84-66-2) | |
30 |
12/07 |
| Diisobutyl Phthalate (DIBP) (CAS No. 84-69-5) | |
7 |
5/10 |
| Diisononyl Phthalate (DINP) (CAS No. 28553-12-0, 68515-48-0, 71549-78-5 and 14103-61-8) | |
8 |
5/10 |
| Diisopropyl Ether (CAS No. 108-20-3) | |
8 |
12/07 |
| Dipentyl Phthalate (DPP) (CAS No. 131-18-0) | |
7 |
5/10 |
| n-Heptane* (CAS No. 142-82-5) | |
15 |
11/09 |
| Hexabromocyclododecane (CAS No. 3194-55-6, 25637-99-5, and 25495-98-1) |
|
17 |
12/07 |
| Hexachlorobutadiene (CAS No. 87-68-3) | |
24 |
12/10 |
| Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (CAS No. 121-82-4) |
|
10 |
12/10 |
| Hexavalent Chromium (Chromium VI ) (CAS No. 18540-29-9) |
|
65 |
11/09 |
| Libby Amphibole Asbestos | |
8 |
3/11 |
| Manganese (CAS No. 7439-9) | |
373 |
4/08 |
| 2-Methylbutane* (CAS No. 78-78-4) | |
4 |
11/09 |
| Methylcyclohexane* (CAS No. 108-87-2) | |
10 |
11/09 |
| 2-Methylpentane* (CAS No. 107-83-5) | |
6 |
11/09 |
| 3-Methylpentane* (CAS No. 96-14-0) | |
6 |
11/09 |
| N-Butanol (CAS No. 71-36-3) | |
12 |
12/07 |
| N-Octane* (CAS No. 111-65-9) | |
12 |
11/09 |
| Naphthalene (CAS No. 91-20-3) | |
34 |
12/10 |
| Polychlorinated Biphenyls (noncancer) (various) | |
383 |
5/10 |
| Tertiary Amyl Methyl Ether (CAS No. 994-05-8) | |
21 |
12/07 |
| Tertiary-Butanol (CAS No. 75-65-0) | |
39 |
12/07 |
| Toxaphene (CAS No. 8001-35-2) | |
102 |
12/07 |
| Trimethylbenzene (1,2,3) (CAS No. 526-73-8) | |
16 |
4/12 |
| Trimethylbenzene (1,2,4 and 1,3,5)
(CAS No. 95-63-6 and 108-67-8 respectively) |
|
25 |
4/08 |
| 2,2,5-Trimethylhexane* (CAS No. 3522-94-9) | |
4 |
11/09 |
| 2,3,3-Trimethylpentane* (CAS No. 560-21-4) | |
4 |
11/09 |
| 2,3,4-Trimethylpentane* (CAS No. 565-75-3) | |
5 |
11/09 |
| Tungsten and related compounds (CAS No. 7440-33-7) (Tungsten, Sodium Tungstate and Tungsten Trioxide) | |
18 7 2 |
12/07 |
| Vanadium pentoxide (CAS No. 1314-62-1) | |
19 |
3/11 |
| Vinyl Acetate (CAS No. 108-05-4) | |
23 |
3/11 |
| Note* These chemicals are listed collectively in the IRIS agenda as alkylates. | |||
The public is also invited to submit information for any chemical currently undergoing peer review and public comment (IRIS External Review Drafts).
Karen A. Hammerstrom
- by phone at: 703-347-8642
- by email at: hammerstrom.karen@epa.gov
History/Chronology
| Feb 2006 | EPA announced the 2006 IRIS Agenda in the Federal Register. [Federal Register Feb 23, 2006] |
| Dec 2006 | EPA announced the 2007 IRIS Agenda in the Federal Register. [Federal Register Dec 22, 2006] |
| Dec 2007 | EPA announced the 2008 IRIS Agenda in the Federal Register. [Federal Register Dec 21, 2007 ] |
| Apr 2008 | EPA introduced three new IRIS chemicals with literature searches and is requesting any additional scientific information on health effects that may result from exposure to these chemical substances. [Federal Register Apr 25, 2008] |
| Nov 2009 | EPA introduced three new IRIS chemicals with literature searches and is requesting any additional scientific information on health effects that may result from exposure to these chemical substances. [Federal Register Nov 2, 2009] |
| May 2010 | EPA introduced four new IRIS chemicals with literature searches and is requesting any additional scientific information on health effects that may result from exposure to these chemical substances. [Federal Register May 7, 2010] |
| Oct 2009 | EPA announced the 2009/10 IRIS Agenda in the Federal Register with an announcement of the IRIS Update Project. [Federal Register Oct 21, 2009] |
| Oct 2010 | EPA announced the 2011 IRIS Agenda in the Federal Register. [Federal Register Oct 18, 2010] |
| Dec 2010 | EPA introduced four new IRIS chemicals with literature searches and is requesting any additional scientific information on health effects that may result from exposure to these chemical substances. [Federal Register Notice Dec 10, 2010] |
| Mar 2011 | EPA introduced four new IRIS chemicals with literature searches and is requesting any additional scientific information on health effects that may result from exposure to these chemical substances. [Federal Register Mar 11, 2011] |
| Apr 2012 | EPA posted literature searches (acetaldehyde (CAS No. 75-07-0) and 1,2,3-trimethlybenzene (CAS No. 526-73-8)) and is requesting any additional scientific information on health effects that may result from exposure to these chemical substances. [Federal Register April 6, 2012] |
| May 2012 | EPA announced the 2012 IRIS Agenda in the Federal Register. [Federal Register Notice May 7, 2012] |
| Jun 2012 | EPA posted the literature search for acrylonitrile (CAS No. 107-13-1) and is requesting scientific information on health effects that may result from exposure to this chemical substance. |
| Jul 2012 | EPA posted the literature search for benzo[a]pyrene (CAS No. 50-32-8) and is requesting scientific information on health effects that may result from exposure to this chemical substance. [Federal Register Notice Jul 16, 2012] |
Additional Information
Instructions for submitting information on IRIS chemical literature search results or the IRIS Agenda
Information should be identified by docket ID number EPA-HQ-ORD-2012-0523 and may be submitted in any of the following five ways:- online at www.regulations.gov;
- by e-mail to ord.docket@epa.gov;
- by regular mail to Office of Environmental Information (OEI) Docket (Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., N.W., Washington, DC 20460-0001; or
- by hand delivery or courier to EPA Docket Center, EPA West, Room 3334, 1301 Constitution Ave., N.W., Washington, DC, between 8:30 a.m. and 4:30 p.m. Monday through Friday, excluding legal holidays .The telephone number for the EPA Docket Center is 202-566-1744. Detailed instructions are provided in the federal register notice under the heading, "How to Submit Information to the Docket."