IRIS Toxicological Review of Nitrobenzene (External Review Draft)
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EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessments of nitrobenzene, that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
Nitrobenzene is used extensively in chemical manufacturing, especially in the synthesis of other industrial chemicals and intermediates. Most important among these is aniline. A re-assessment of the potential health effects of nitrobenzene has been undertaken. The draft assessment will present reference values for the noncancer effects (RfD and RfC) and a cancer assessment (IUR).
Combined with specific exposure information, government and private entities can use IRIS to help characterize public health risks of chemical substances in a site-specific situation and thereby support risk management decision designed to protect public health.
|Mar 2007||EPA released the external review draft for public review and comment.|
|May 2007||EPA hosted an independent peer review panel workshop to discuss the draft report.|
|Feb 2009||EPA released the final Toxicological Review of Nitrobenzene: in support of the Integrated Risk Information System (IRIS).|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.