IRIS Toxicological Review and Summary Documents for 2,2,4-Trimethylpentane (External Review Draft)
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EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 2,2,4-trimethylpentane, also called TMP, that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
The current TMP assessment posted on IRIS (1991) does not include an evaluation of the oral noncancer database or the cancer database, and contains a message for the inhalation RfC that the health effects data for TMP were reviewed by the U.S. EPA RfD/RfC Work Group and were determined to be inadequate for the derivation of an inhalation RfC. An evaluation of the TMP database is not available from other agencies. As a part of the IRIS nomination process for selecting chemicals for assessment, a quick literature review of the database was conducted in 2003. While no new critical studies via the inhalation route were identified, newer mechanistic studies, gavage studies, and toxicokinetic studies were found. This information has been used to update the assessment.
|1991||EPA completed a final assessment on the Toxicological Review for 2,2,4-Trimethylpentane.|
|2006||EPA began reviewing the Tox Assessment of TMP. While no new critical studies via the inhalation route were identified, newer mechanistic studies, gavage studies, and toxicokinetic studies were found. This information was used to update the assessment.|
|Dec 2006||EPA released the external review draft for public review and comment.|
|Feb 2007||EPA hosted an independent peer review panel workshop to discuss the draft report.|
|Jul 2007||EPA released the final Toxicological Review of 2,2,4-Trimethylpentane : in support of the Integrated Risk Information System (IRIS).|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.