Exposures and Internal Doses of Trihalomethanes in Humans: Multi-Route Contributions from Drinking Water (Final)
The National Center for Environmental Assessment (NCEA) has released a final report that presents and applies a method to estimate distributions of internal concentrations of trihalomethanes (THMs) in humans resulting from a residential drinking water exposure. The report presents simulations of oral, dermal and inhalation exposures and demonstrates the feasibility of linking the US EPA’s information Collection Rule database with other databases on external exposure factors and physiologically based pharmacokinetic modeling to refine population-based estimates of exposure.
Topics covered include:
- Data Quality and Assumptions
- Modeling and Integration Framework: concentrations of THMs in drinking water, water use patterns, human in-home behavioral characteristics, room volumes and ventilation, physiologically based pharmacokinetic modeling.
- Required Data.
- Population distributions of internal doses in the adult male, adult female and 6 year old child resulting from household contact with drinking water.
- Contributions of oral, dermal and inhalation routes to attained internal concentrations of THMs.
|Jun 2003||Feasibility document published.|
|Sep 2003||Simplified acquisition awarded to Wilkes Technologies, Inc.|
|Jan 2004||Contractor report received.|
|Sep 2004||Peer review contract established.|
|Mar 2005||Internal Agency Review completed.|
|Jun 2005||External Panel Review of final report reviewed.|
|Dec 2005||Simplified acquisition developed to refine the description of the model and documentation of parameter values.|
|Nov 2006||EPA Releases the final report.|
- (251 pp, 3 MB, about PDF)