Framework for Assessing Health Risk of Environmental Exposure to Children (External Review Draft)
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.
The draft document, Framework For Assessing Health Risks of Environmental Exposure to Children, can serve as a resource on children's health risk assessment and it addresses the need to provide a comprehensive and consistent framework for considering children in risk assessments at EPA. This framework lays out the process, points to existing published sources for more detailed information on life stage-specific considerations, and includes web links to specific on-line publications and relevant Agency science policy papers, guidelines and guidance. The document emphasizes the need to take into account the potential exposures to environmental agents during preconception and all stages of development and focuses on the relevant adverse health outcomes that may occur as a result of such exposures. This draft report will be externally peer-reviewed in the next three or four months by an independent panel of experts prior to making the report final.
Major findings and conclusions: The draft report outlines the framework in which mode of action(s) (MOA) can be considered across life stages. The framework is based upon existing approaches adopted in the Framework on Cumulative Risk Assessment and identifies existing guidance, guidelines and policy papers that relate to children's health risk assessment. It also emphasizes the importance of an iterative approach between hazard, dose response, and exposure analyses.
Key science/assessment issues: The draft framework addresses the questions of why and how an improved children's health risk assessment will strengthen the overall risk assessment process across the Agency. This approach improves the scientific explanation of children's risk and will add value by: 1) providing for a more complete evaluation of the potential for vulnerability at different life stages, including a focus on the underlying biological events and critical developmental periods for incorporating MOA considerations; 2) evaluating of the potential for toxicity after exposure during all developmental life stages; and 3) integrating of adverse health effects and exposure information across life stages.
- Problem formulation step - Focuses on the life stage-specific nature of the analysis to include scoping and screening level questions for hazard characterization, dose response and exposure assessment.
- Analysis step - Focuses on a life stage approach to evaluating hazard, dose-response and exposure that is relevant to the scope of the problem identified in problem formulation.
- Risk characterization step - Recognizes the need to consider life stage-specific risks and explicitly describes the uncertainties and variability in the database.
|Jan 2004||The Children Health Risk Assessment (CHRA) Workgroup was formed to collect information related to these documents.|
|Oct 2004||An Internal Peer Review was conducted on the initial draft documents.|
|Mar 2005||Briefed the Office of Children's Health Protection (OCHP) children's Federal Advisory Committee Act (FACA). Then presented an overview of the CHRA framework at the Human Health Research Board of Scientific Counselors (BOSC) program review & at the 2005 Society of Toxicology (SOT) Conference.|
|Jun 2005||Incorporated peer review suggestions into the final report and then presented at the EPA Regional Risk Assessors Meeting & at the EPA 2005 Science Forum.|
|Nov 2005||Presented an overview of the CHRA framework at the World Health Organization (WHO) 2005 Meeting.|
|Dec 2005||Presented an overview of the CHRA framework at the Society for Risk Assessment (SRA) meeting.|
- International Life Sciences Institute (ILSI), 2003, Workshop to Develop a Framework for Assessing Risks to Children from Exposures to Environmental Agents. Risk Science Institute, Washington, DC: ILSI Press. Available at: http://rsi.ilsi.org/NR/rdonlyres/1B183267-ADF3-4FEC-9CA2-339DD1482FC2/0/WorkshopReportFinal.pdf
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.