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Environmental Assessment

IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft)

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Report Information

EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of carbon tetrachloride that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.

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Susan H. Rieth
  • by phone at:   703-347-8582
  • by email at:  rieth.susan@epa.gov


Carbon tetrachloride has been used as a dry-cleaning agent, fabric-spotting fluid, solvent, reagent in chemical synthesis, fire extinguisher fluid, and grain fumigant, but its primary use was in chlorofluorocarbon (CFC) production. Production of this chemical peaked in the early 1970s; annual production has generally declined since the mid-1970s. The Consumer Product Safety Commission banned the use of carbon tetrachloride in consumer products in the 1970s. Decline in the use of carbon tetrachloride also accompanied EPA’s increased regulation of the use of CFCs in propellants, and the Montreal Protocol, which was implemented in the U.S. via Title VI of the Clean Air Act Amendments of 1990 and that called for a ban (with certain exemptions) on production and import of carbon tetrachloride.


1987EPA posts the Carbon Tetrachloride IRIS assessment on the IRIS database (RfD and cancer assessment)
May 2008EPA released the external review draft for public comment. [Federal Register Notice May 21, 2008]
Jun 2008EPA announces the public listening session. [Federal Register Jun 24, 2008 ]
Sep 2008EPA EPA announced the external peer review meeting to be held on October 14, 2008. [Federal Register Sep 9, 2008]
Nov 2008EPA released the comments from the public comment period and external review meeting.
Nov 2009EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Carbon Tetrachloride.
Mar 2010EPA released the Toxicological Review and IRIS Summary for Carbon Tetrachloride and the interagency review draft with interagency review comments.

Next Steps

Following the External Peer Review, the final assessment will be published on the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2008-0058 (for the docket ID) to comment on this report.


U.S. EPA. IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/005A.


This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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