Environmental Assessment
IRIS Toxicological Review of Tetrahydrofuran (THF) (External Review Draft)
IRIS Toxicological Review of Tetrahydrofuran (THF) (External Review Draft)
Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.
Federal Register Notices
Contacts
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Notice
EPA announces the release of the Toxicological Review of Tetrahydrofuran and notice of the External Peer Review Panel Meeting in the August 20, 2007 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within the external review period (next 60 days) will be provided to the peer reviewers prior to the meeting for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions.
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of tetrahydrofuran (THF) that when finalized will appear on the Integrated Risk Information System (IRIS) database.Background
This is EPA's first assessment of noncancer health effects and carcinogenic potential of tetrahydrofuran. The IRIS program is preparing an assessment that will incorporate updated health effects information available for tetrahydrofuran and current risk assessment methods.
The IRIS assessment of tetrahydrofuran will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physiochemical and toxicokinetic properties of chemical, and its toxicity in humans and experimental systems. The assessment will present reference values for the noncancer effects of tetrahydrofuran (RfD and RfC), and a cancer assessment. The Toxicological Review and IRIS Summary will undergo Agency review, Interagency review, and external scientific peer review. The final product will reflect the Agency opinion on the overall toxicity of tetrahydrofuran.
History/Chronology
Aug 2007 | EPA releases the first External Review Draft for public review and comment. |
Next Steps
Downloads/Related Links
- Toxicological Review of Tetrahydrofuran (External Review Draft) (PDF) (159 pp, 1 MB, about PDF)
- Draft Charge to External Reviewers for the Toxicological Review of Tetrahydrofuran (THF) (PDF) (4 pp, 24 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (58 pp, 323 KB, about PDF)
Additional Information
Citation