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Environmental Assessment

Recent Additions for 2005

Recent Addition items from past years

December 23, 2005
The Summary of n-Hexane has been revised and an updated Toxicological Review has been added to the IRIS Web site at http://www.epa.gov/iris
December 09, 2005
Environmental Protection Agency (EPA) is undertaking to update and revise, where appropriate, the Air Quality Criteria for Oxides of Nitrogen, EPA/600/8-91/049aF-cF, published in August 1993 by the Office of Research and Development, National Center for

Environmental Assessment. Interested parties are invited to assist the EPA in developing and refining the scientific information base for updating the Air Quality Criteria for Oxides of Nitrogen by submitting research studies that have been published, accepted for publication, or presented at a public scientific meeting. This was announced in a December 9, 2005 Federal Register Notice.
December 01, 2005
EPA is releasing the document, Air Quality Criteria for Lead (First External Review Draft), Volumes I & II for public comment and review by EPA's Clean Air Scientific Advisory Committee (CASAC) in an effort to update the 1986 final version of the document. Full details can be found in the [Federal Register Dec 2, 2005].
November 30, 2005
EPA will be sending several Scientists to present at this years Society For Risk Analysis (SRA) Annual Meeting December 4-7, 2005 in Orlando, Florida. Agenda links, EPA presentation details and more information are available.
October 21, 2005
EPA has just released the following Additional Proposed Indicators for the U.S. EPA's 2007 Report on the Environment Technical Document for an independent external peer review and a 30-day public review and comment period. The public comment period ends November 21, 2005 and written comments should be sent to EPA, as indicated in the [Federal Register Oct 21, 2005 ].
October 14, 2005
EPA Announces a Scientific Peer-Review Meeting to Review the Draft Document: Approaches for the Application of Physiologically-Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment (EPA/600/R-05/043A) in the [Federal Register Oct 14, 2005].
October 14, 2005
Environmental Protection Agency Science Advisory Board (SAB) announces a public meeting of the SAB All-Ages Lead Model Review Panel for the purpose of providing the Agency with advice and recommendations on the recently-developed All-Ages Lead Model (AALM) in the October 14, 2005 Federal Register Notice.

The public comment period has recently been extended to December 12, 2005 as described in the [Federal Register Nov 3, 2005].
September 27, 2005
The All-Ages Lead Model (AALM) version 1.05, is an external review draft software and guidance manual. EPA is releasing this software and associated documentation for public review and comment beginning September 27, 2005, until October 27, 2005. The public comments will be accepted, as indicated in the [Federal Register Sep 27, 2005].
September 23, 2005
The Summary of Toluene has been revised and an updated Toxicological Review has been added to the IRIS Web Site.
September 08, 2005
EPA to host an external peer-review workshop to review the draft report, "The Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the U.S.: the Year 2000 Update," March 2005 (EPA/600/P/03/002a) from September 13 - 15, 2005 as described in the (see [Federal Register Aug 12, 2005]).
September 01, 2005
EPA will be sending several NCEA Scientists to present at this years Society For Risk Analysis (SRA) Annual Meeting December 4-7, 2005 in Orlando, Florida. The agenda and some presentations are available here.
August 31, 2005
EPA is releasing the document, Air Quality Criteria for Ozone and Related Photochemical Oxidants (Second External Review Draft), for public comment and review by EPA's Clean Air Scientific Advisory Committee (CASAC) in an effort to update the 1996 version of the document.
August 30, 2005
The National Center for Environmental Assessment (NCEA) is recruiting for three leadership positions in the Integrated Risk Information System (IRIS) Program. All of the positions are interdisciplinary (GS-401/415/601/1301-15) and are located in Washington, DC. The vacancy announcements are accessible via the Agency's EZhire Web site and USAJOBS Exit EPA's Web Site and close on 09/16/05.
August 26, 2005
EPA has released a report entitled, " A Cross-Species Mode of Action Information Assessment: A Case Study of Bisphenol A." (PDF, 98pp, 2 MB, About PDF) This report describes an approach to predict chemical effects and mode of action (MOA) for animal species without data from MOA information for species with data, and a case study to demonstrate the approach.
August 26, 2005
This document is the final report for the 2005 peer consultation workshop to seek expert opinion on research needs related to the mode of action of the inhalation carcinogenicity of naphthalene. A panel of expert participants met to discuss their responses to the charge questions on April 7, 2005. This report is a summary of the main points of presentations and highlights discussions among the participants.
August 23, 2005
EPA is extending the public comment period on the external review draft document titled, "Approaches for the Application of Physiologically-Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment" (EPA/600/R-05/043A), until October 14th as stated in the updated [Federal Register Aug 22, 2005].
August 15, 2005
The IRIS Program added statements to certain existing IRIS Summaries confirming that the health effects information upon which the assessment was based is still current. This is to follow up on their February 9, 2004 FR notice (69 FR 5971) announcing the annual IRIS agenda. In that notice, EPA announced that they would use findings from a recent IRIS literature screening project (the results of which were added to IRIS in 2003) as the basis for a systematic update of the IRIS database.
August 12, 2005
EPA is announcing an external peer-review workshop to review the draft report, "The Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the U.S.: the Year 2000 Update," March 2005 (EPA/600/P/03/002a) as stated in the [Federal Register Aug 12, 2005].
August 03, 2005
A revised summary for Zinc and compounds and accompanying Toxicological Review (PDF, 83 pages, 519 Kb, about PDF) have been added to the IRIS Web site.
August 02, 2005
The Summary of Zinc and Compounds has been revised and an updated Toxicological Review has been added to the IRIS Web site. The oral reference dose (RfD) was based on four different human clinical studies, however, it is similar to that assessed in 1991. This assessment was conducted in response to the request from the Office of Water. Available information were inadequate for non-cancer inhalation reference concentration (RfC) and cancer assessments. EPA/635/R-05/002.
July 29, 2005
This draft report addresses the application and evaluation of PBPK models for risk assessment purposes. These models represent an important class of dosimetry models that are useful for predicting internal dose at target organs for risk assessment applications. This report is primarily meant to serve as a learning tool for EPA scientists and risk assessors who may be less familiar with the field. In addition, this report can be informative to PBPK modelers within and outside the Agency, as it provides an assessment of the types of data and models that the EPA requires for consideration of a model for use in risk assessment.
July 15, 2005
The U.S. Environmental Protection Agency (EPA) Office of Research and Development's National Center for Environmental Assessment (NCEA) is reviewing and, as appropriate, revising the EPA document, "Air Quality Criteria for Lead," EPA-600/8-83/028aF-dF (published in June 1986) and an associated supplement (EPA-600/8-89/049F) published in 1990. As part of this process, several workshops are planned to discuss, with invited recognized scientific experts, initial draft materials that deal with various lead-related issues being addressed in the revised "Lead Air Quality Criteria Document" (Lead AQCD) now being prepared by NCEA as described in the July 15, 2005 Federal Register Notice.
July 14, 2005
The IRIS Program has updated the IRIS Glossary by adopting the revised definitions for the reference dose (RfD) and reference concentration (RfC) to implement the recommendations of the RfD/RfC Technical Panel as provided in the report, "A Review of the Reference Dose and Reference Concentration Processes," EPA/630/P-02/002F (U.S. EPA, 2002).
July 11, 2005
A revised summary for Barium and compounds and accompanying Toxicological Review (PDF, 87p, 258Kb, About PDF) have been added to the IRIS web site. The oral reference dose (RfD) was revised in response to a Request for Correction (RFC #2293) (PDF, 77p, 307 Kb, About PDF) submitted under the Information Quality Guidelines (IQGs). The noncancer inhalation and cancer assessments were not revised.
July 08, 2005
EPA releases the position paper, "An Evaluation of the Human Carcinogenic Potential of Ethylene Glycol Butyl Ether (EGBE)," developed in support of the Agency's evaluation of a petition from the American Chemistry Council requesting EPA to delist EGBE per the Clean Air Act Amendments (CAAA), Title III, section 112(b)(1). The position paper was a key component of the Agency's recent determination to grant this petition. It will also be used in the Agency's IRIS assessment of ethylene glycol butyl ether (EGBE). For more information about IRIS, visit http://www.epa.gov/iris.
July 08, 2005
NCEA's 2005 Science Forum Posters: On May 16-18, 2005, EPA held its 4th annual Science Forum in Washington, DC. The 2005 EPA Science Forum - Collaborative Science for Environmental Solutions - was an opportunity to showcase EPA's scientific accomplishments, demonstrate EPA's commitment to quality science, and highlight the impact of science in EPA decision-making. An important part of the Science Forum is the presentation of posters that describe and illustrate some of these scientific accomplishments in a concise and approachable format. The 15 science posters presented by NCEA at this year's Forum are now available on the NCEA web site. Posters presented by scientists in other parts of ORD are available for viewing at...http://www.epa.gov/ord/scienceforum/2005/.
June 14, 2005
National Center for Environmental Assessment (NCEA) seeks five (5) immediate openings for non-laboratory, postdoctoral positions which would be ideal for scientists interested in the application of toxicological, epidemiological and environmental data to support development of human health and environmental risk assessments and science policies related to risk assessment.
June 06, 2005
EPA has released for external peer review and public comment the proposed indicators that may be included in the EPA's 2006 Technical Document on the Report on the Environment. The June 6, 2005, Federal Register notice announced the availability of the proposed indicators for review and comment, the start of the 45-day public comment period, and an independent external peer review workshop to be held on July 27-29, 2005.
May 31, 2005
This document is the final report for the 2005 external peer review for the IRIS Reassessment of n-hexane, prepared by the U.S. Environmental Protection Agency (EPA), National Center for Environmental Assessment (NCEA), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on March 30, 2005. This document contains the final written comments of the external peer reviewers.
May 06, 2005
The Environmental Protection Agency (EPA) announces the release of the report, The Inventory of Sources of Dioxin in the United States (External Review Draft 2005).
May 02, 2005
The Environmental Protection Agency (EPA) is announcing the release of the report, Predicting Toxicity to Amphipods from Sediment Chemistry.
April 27, 2005
The Environmental Protection Agency (EPA) is announcing the release of the external review draft of the Causal Analysis/Diagnosis Decision Information System (CADDIS) on-line tool. [ More info]
March 29, 2005
On March 29, 2005 EPA issued final Guidelines for Carcinogen Risk Assessment, along with an associated document entitled Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. Both documents are available at www.epa.gov/cancerguidelines

March 08, 2005
Environmental Protection Agency (EPA) is announcing a workshop to seek expert opinion on the research needs related to the mode of action of the inhalation carcinogenicity of naphthalene. EPA will consider the comments and recommendations from the expert panel in determining a future course of action for assessing potential health risks associated with naphthalene exposure. The workshop will begin on April 7, 2005.
[Federal Register Mar 8, 2005] [FRL-7882-1].
March 01, 2005
An interagency conference sponsored by Tri-Service (Air Force, Army, Navy) Toxicology; the U.S. EPA, Office of Research and Development, National Center for Environmental Assessment; Agency for Toxic Substances and Disease Registry, the Division of Toxicology; and the National Institute for Occupational Safety and Health. The conference is held with the cooperation of the National Research Council/ National Academy of Sciences.
February 24, 2005
EPA has developed four issue papers that highlight important scientific issues related to Trichloroethylene (TCE). These papers were provided to the National Academy of Science (NAS) on February 15, 2005 and now are available on-line.
February 18, 2005
A new summary for Perchlorate and Perchlorate Salts has been added to the IRIS Web site. The summary is based on "Health Implications of Perchlorate Ingestion" by the National Research Council of the National Academies (NRC, 2005).

February 11, 2005
EPA's IRIS Program is announcing that an external peer-review panel meeting to review the draft document entitled, "Toxicological Review of N-Hexane: In Support of Summary Information on the Integrated Risk Information System (IRIS)" (NCEA-S-1605) was published in the [Federal Register Feb 11, 2005 [FRL-7872-2 ; E-docket No.: ORD-2005-0007]].
January 31, 2005
The first external review draft of the revised Air Quality for Ozone and Related Photochemical Oxidants (EPA 600/R-05/004aA-cA) is now being released for a 90-day public comment period and for review by the Clean Air Scientific Advisory Committee (CASAC). As required by the Clean Air Act, the U.S. Environmental Protection Agency (EPA) Office of Research and Development's National Center for Environmental Assessment (NCEA) is reviewing and, as appropriate, revising the EPA document, Air Quality Criteria for Ozone and Related Photochemical Oxidants, EPA-600/AP-93/004aF-cF, published in 1996.
January 10, 2005
A draft of EPA's Project Work Plan for Revised Air Quality Criteria for Lead is being released for public comment. The Project Work Plan describes the managerial procedures for reviewing and, as appropriate, revising EPA Air Quality Criteria for Lead ( EPA 600/8-83/029aF-dF) and the associated supplement (EPA 600/8-89/049F).

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