Health Assessment Document for Polychlorinated Dibenzo-P-Dioxins (1985)
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The health assessment document on polychlorinated dibenzo-p-dioxins discusses multimedia environmental issues pertaining to the most toxic chlorinated dioxins, namely, 2,3,7,8-tetrachloro-; 1,2,3,7,8-pentachloro-; 1,2,3,6,7,8-hexachloro-; and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins. Scientifically valid data essential for human health risk assessment purposes from an extensive literature search have been compiled and discussed critically. Discussions are based on physiochemical properties and analytical methodologies; stability and degradation; production, use, synthesis; environmental resources and environmental levels; environmental ffate and transport; degradation; bioaccumulation and bioconcentration factors; ecological effects; various aspects of toxic effects from acute, subchronic and chronic exposures in experimental animals and humans; pharmacokinetics and mechanism of toxic effects; teratogenicity and reproductive effects; mutagenicity and carcinogenecity. Based on this review, critical studies have been identified and utilized for estimating the unit risk.