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Model Report

Web-based Interspecies Correlation Estimation

Last Revision Date: 09/24/2014 View as PDF
General Information Back to Top
Model Abbreviated Name:

Model Extended Name:

Web-based Interspecies Correlation Estimation
Model Overview/Abstract:
Web-ICE estimates acute toxicity (LC50/LD50) of a chemical to a species, genus, or family from the known toxicity of the chemical to a surrogate species. Web-ICE has modules to predict acute toxicity to aquatic (fish and invertebrates) and wildlife (birds and mammals) taxa for use in ecological risk assessments, and also contains modules that generate Species Sensitivity Distributions (SSDs) from Web-ICE generated data.
Keywords: Acute toxicity, aquatic organisms, wildlife, species sensitivity distributions
Model Technical Contact Information:
Agency Contact:
Sandy Raimondo
Model Homepage: http://www.epa.gov/ceampubl/fchain/webice/index.html
Substantive Changes from Prior Version: N/A
Plans for further model development: New update posted late 2009 to include endangered species module and updated aquatic models

User Information Back to Top
Download Information
Model data available at:
Using the Model
Basic Model Inputs
Acute toxicity (e.g. LC50/ LD50)
Basic Model Outputs
Acute toxicity (e.g. LC50/ LD50) / Species sensitivity distributions
User Support
User's Guide Available?
Availability of User Support
User Qualifications

Model Science Back to Top
Problem Identification
Predict acute toxicity to aquatic organisms and wildlife when toxicity is unknown.
Summary of Model Structure and Methods
Least squares linear regressions
Model Evaluation
  • Code verification followed Quality Assurance Project Plan
  • model results verified through cross-validation
  • Sensitivity analysis – n/a; empirical relationship
  • Uncertainty analyses conducted to determine influence of species taxonomic relatedness, chemical mode of action, acute test conditions, and model parameters.
  • Multiple peer review articles published on model application and technical basis.
Key Limitations to Model Scope
Model development dependent on known toxicities for multiple chemicals and species. Models are limited to available data.
Case Studies
Awkerman, J., S. Raimondo, and M.G. Barron. 2008. Development of Species Sensitivity Distributions for wildlife using interspecies toxicity correlation models. Environmental Science and Technology. 42 (9): 3447-3452.

Dyer, S. D., D.J. Versteeg, S.E. Belanger, J.G. Chaney, S. Raimondo and M.G. Barron. 2008. Comparison of Species Sensitivity Distributions derived from interspecies correlation models to distributions used to derive water quality criteria. Environmental Science and Technology. 42 (8): 3076-3083.

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