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Model Report

Cumulative Aggregate Risk Evaluation Software

Last Revision Date: 10/08/2009 View as PDF
General Information Back to Top
Model Abbreviated Name:

Model Extended Name:

Cumulative Aggregate Risk Evaluation Software
Model Overview/Abstract:
CARES is a state-of-the-art software program designed to conduct complex exposure and risk assessments for pesticides, such as the assessments required under the 1996 Food Quality Protection Act (FQPA). CARES was originally developed under the auspices of CropLife America (CLA), which conceived the project, provided funding, and oversaw the program’s evolution. Scientific and technical contributions to the program’s development came from a broad team of experts, including scientists from CLA’s member companies and staff, consulting companies, and the USEPA and USDA. With its transfer to the ILSI Research Foundation, the CARES program and source code will continue to be publicly available at no charge. Also, the full range of stakeholders will be invited to contribute to the technical and scientific advancement of CARES.
Keywords: Residue, consumption, diet, commodity, chemical, Monte Carlo, probabilistic, stochastic, random, exposure, risk, MOE, RfD, NOAEL, Sub-population
Model Technical Contact Information:
Agency Contact:
David Hrdy
Health Effects Division
Office of Pesticide Programs
Office of Prevention, Pesticides, and Toxic Substances
US Environmental Protection Agency

Developer Contact:
Dr. Muhilan Pandian
http://www.infoscientific.comexit EPA
2240 Village Walk Drive, Suite 2310
Henderson, NV 89052

Model Homepage: http://cares.ilsi.org Exiting the EPA Site
Substantive Changes from Prior Version: Revised FCID food list
Updated Chem/Tox module
Chronic exposure/risk assessment
Enhanced water module
Water residue weighting factor
Residential Wizard
Source Accumulator Plus
Dietary minute module (DMM)
PDP data tables
New CARES User Guide
Optimized coding
Plans for further model development: Providing easier means of entering residue information and simplifying the process that matches residues with consumption.

User Information Back to Top
Technical Requirements
Computer Hardware
For CARES installation, it is recommended that you have at least
  • A Pentium (1.0 GHz or faster CPU) with 512 MB of RAM
  • A video display capable of 1024 by 768 with at least 256 colors
  • At least 20 GB of free hard disk space
Compatible Operating Systems
Microsoft© Windows 2000 (SP3 or higher), or XP.
Other Software Required to Run the Model
CARES requires installation of certain Microsoft© components prior to its installation. These components are MDAC and Jet. Depending on your system configuration, you may not need mdac.exe and/or jet.exe. The CARES installation process will determine which package is needed (if any) and install automatically.
Download Information
http://cares.ilsi.org/careslicense.htmexit EPA
Using the Model
Basic Model Inputs
Residue in parts per million to calculate exposure, NOAEL or Reference dose to calculate risk.
http://cares.ilsi.org/NR/rdonlyres/FA933FF2-133F-4F56-B97A-096DA49525E4/0/6QRG_rev20Sep04.pdfexit EPA
Basic Model Outputs
Exposure in mg/kg/day or mg/day. Risk in percent of the Reference Dose and Margin of Exposure when using a NOAEL.
User Support
User's Guide Available?
http://cares.ilsi.org/CaresGuides.htmexit EPA
Other User Documents
http://cares.ilsi.org/CARESInfo.htmexit EPA
Availability of User Support
User Qualifications
Some background in residue chemistry, an understanding of the basic commodity relationship as ingredient in recipes, and an understanding of toxicology with regards to risk assessment.

Model Science Back to Top
Problem Identification
Food Quality Protection Act
Summary of Model Structure and Methods
http://cares.ilsi.org/CaresGuides.htmexit EPA
Model Evaluation
Key Limitations to Model Scope
It is a large memory that requires a fast processor and large hard drive space but it is capable of performing very sophisticated assessments.
Case Studies

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